We are seeking a talented and highly motivated computational chemist with a strong background in Structure Based Drug Design to join our team. The Nurix mission is to control protein fate to treat human diseases by leveraging an exciting new drug discovery technology called targeted protein degradation, working on many classes of drug targets.

The successful candidate will develop and apply state-of-the-art computational software, computer aided drug design and simulation techniques as part of a highly integrated team of computational chemists, structural biologists, medicinal chemists and discovery biologists. Your creative thinking will push forward the frontiers of modelling for targeted protein degradation, which includes a class of compounds that fall outside of the small molecule chemical space. Since these compounds bridge the targeted protein and degrader protein, you will develop methods to describe these complexes from a 3-dimensional standpoint, and work with medicinal chemists and others to optimize the interactions of these compounds in the overall complex formed.  You will work closely with DNA encoded library technologies to help drive hit discovery. You will be part of a dynamic multi-disciplinary team focused on moving projects from the hit identification stage to the discovery of clinical candidates

Qualifications:

• Ph.D. in Chemistry, Biology, Physics, Computer Science, Bioinformatics, Biochemistry, Biophysics, or related disciplines
• Demonstrated skills in computer aided drug design
• Excellent understanding of protein-ligand interactions and the physiochemical properties of compounds
• Practical working experience in computational chemistry software (e.g. Schrodinger, OpenEye, others)
• Proven track record in one or more of the following: docking studies, virtual screening, druggability analysis, structure-based design for lead optimization, free energy perturbation and MD simulation
• Excellent communication of design rationale, key experimental results, issues and accomplishments in appropriate verbal and written form 
• Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations 
• Maintains an excellent scientific expertise in the latest developments in computational chemistry
• Good ability to manage own priorities and deliverables, both independently and in the team setting
• Ability to work effectively in a highly interdisciplinary team and able to prioritize tasks across multiple projects
• Working knowledge of medicinal, synthetic, and physical organic chemistry principles
• Software development skills in a modern programming language (eg Python) and developing computational workflows is a strong plus
• Industry or comparable academic experience with small molecule drug design (0-3+ years)

Fit with Nurix Culture and Values 

• Strong team orientation; highly collaborative 
• Solutions and results-oriented focus 
• Hands-on approach; resourceful and open to diverse points of view 

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

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Candidate with a demonstrated experience (20 years+) managing large data-centric projects in drug discovery/pharmaceutical/biomedical industry, with proven skills in R&D data management, business intelligence/analytics, database administration and information infrastructure, software development, and cloud-based computational technologies.

The position consists of evaluating, proposing, and implementing cost effective, cross functional data management, high performance solutions to serve all Research, Clinical Development, and Business teams data and providing relevant information for any decision-making requirements. The candidate must have a passion for solving technical challenges and building collaborative, cross functional relationships with peers, supervisors, and team members.

Responsibilities:

• Executive Management of all computational resources, private clouds, internal databases and information repository, with proven experience managing AWS Services, Public/Private/Hybrid Clouds strategy, configuration and administration.
• Databases and related Data Services Administration, Monitoring, Optimization, and Support to ensure 24/7 uptime. While Nurix utilizes all database servers flavors, a strong Oracle DBA experience is required for this position.
• Harmonization & Normalization of all key Drug Discovery and Research data w/ a central Master Data Management Plan, and centralization of all information in Nurix Proprietary databases (i.e. NxVision).
• Complete Data Management Support for all Business, Alliance Management, Research, Clinical Development teams including support for: Data Capture, Data Reporting & Dashboarding, ad-hoc Import/Export for any data requests. Working closely with the Biometrics and Clinical teams to ensure data availability, quality, compliance, and security.
• Evaluation, implementation, support, and management of all company private and vendor cloud solutions (AWS, Oracle, Microsoft, SaaS solutions, etc.) and management of all Data Integrations between these solutions (Research, Clinical, GxP).
• Provide technical data management and databases support for all Software Development initiatives; Delphi, NxVision, LIMS, or any Lab Systems and Research Operations Development. This including ensuring data availability for any Software Development, Testing, UAT, Training.
• Support CMC Technical Lead for Investigational Drug Supply Chain, Distribution, GMP Manufacturing & Inventory Distribution information (purchasing, sales, inventory, shipping, track-trace, raw material to finished goods to sales.
• Extensive knowledge of many information systems used in Drug Discovery, Research, Genomics, ChemInformatics, Clinical Development, and Clinical Informatics, Quality Assurance, Software and Data, including Public Databases Integration and Support.
• Participate as need in any Clinical and Drug Safety data reporting/analytics to support the Nurix Preclinical and Clinical studies.

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

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The Clinical Trial Associate supports Clinical Operations by performing a variety of administrative and operational activities associated with all phases of clinical trials.

Required Qualifications

• Bachelor’s degree (BS/BA) or equivalent combination of education and work experience in science related field
• Clinical Operations or clinical research-related experience is desired (1-2 years)
• Familiarity with document filing/management in an electronic Trial Master File preferred
• Strong attention to detail in composing and proofing materials, establishing priorities, scheduling, and meeting deadlines
• Excellent verbal and written communication skills
• Proficiency with MS Word, Excel, Outlook, and PowerPoint

Responsibilities:

• Assist in the development, review, and formatting of study-specific documents, including plans, manuals, CRFs, patient documents, reference documents, and study tools
• Develop study-specific TMF plan(s) and manage/oversee collecting, tracking, and archiving of Essential Documents throughout the life of the study
• Conduct quality reviews of the TMF and work with CRO to resolve discrepancies
• Assist in the coordination and tracking of clinical supplies and laboratory samples
• Participate in the review of clinical data in the clinical database, data listings, and reports
• Assist with data reconciliation of various systems, as required
• Coordinate preparation of study-specific training materials, as required
• Maintain and update study trackers/metrics on an on-going basis
• Facilitate the preparation of meeting agendas and take meeting minutes for clinical team meetings
• Attend Investigator Meetings and/or support meeting planning
• Complete additional tasks as assigned and agreed upon

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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Nurix, Inc. is seeking a Clinical Trial Manager (CTM)/Sr. CTM to join the Clinical Operations team.  This individual will be responsible for management of global clinical programs. They will lead study team, vendors, clinical monitors, and clinical sites throughout the life cycle of a clinical trial.

This individual will be able to manage clinical trial(s) and have broad involvement in work central to Nurix’s strategic goals. They will apply existing technical skills, learn new skills, and play a key role in nonclinical development of the programs and help grow the company and guide its direction. As an early hire, they’ll be influential in championing and developing Nurix’s culture.

CTM/Sr. CTM is responsible for the successful implementation of a clinical trial, independently, from start-up to close-out. Experience in managing cross-functional teams, knowledge of applicable regulatory requirements and developing junior staff will be essential to the team’s success. The CTM/Sr. CTM will represent Clinical Operations at Project team meetings and may represent Nurix at professional events.

Responsibilities:

• Accountable for all operational aspects of assigned clinical trial(s)
• Responsible for selection of vendors/CROs and provide effective ongoing management to vendors/CROs to ensure compliance and execution of deliverables within the approved budget, study timeline, and study protocol.
• Works closely with investigative site personnel, CROs, and other study vendors
• Monitor and track clinical trial progress and provide status update to stakeholders
• Manage study contracting, budget, forecasting, accruals, and payment process for all clinical trial vendors including investigational sites
• Collaborate with Data Management to ensure correct CRFs content is collected, prepare/implement CRF completion guidelines, and coordinate delivery of data listings and study reports
• Drafts and coordinates review of relevant documents including protocols, informed consents, case report forms, monitoring plans, investigator brochures and clinical study reports.
• Must be able to participate in cross-functional strategic initiatives under limited supervision
• Proactively identifies potential issues/risks and recommends/implements solutions.
• Provides leadership to the clinical operations team working on the assigned program.

Experience and Skills:

• B.S./ B.A. in biological sciences, advanced degree preferred with 5+ years of relevant industry experience
• Ability to travel as required for the program (10-15%)
• Demonstrated knowledge of FDA, ICH and GCP regulations and guidelines
• Experience in leading teams, including CROs, consultants and vendors.
• Must display strong analytical and problem-solving skills at a project level and collaborate with colleagues to generate solutions
• Strong communication and influence skills and ability to create a clear sense of direction
• Ability to deal with time demands, incomplete information or unexpected events
• Outstanding organizational skills with the ability to multi-task and prioritize
• Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

About the Position

We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library collection. DEL synthesis requires a hybrid of techniques that are borrowed from chemistry environments: chemical reaction setup, LCMS analysis, SAR evaluation, split and pool library synthesis workflows, parallel reaction development, as well as from biology laboratories:  aqueous buffer preparation, centrifuge use, ethanol precipitation of DNA, A260 DNA quantification, gel electrophoresis, bioanalyzer analysis, enzymatic DNA ligation.  An exposure to some of these techniques is helpful in training into a DNA encoded scientist.  As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

• B.S. or M.S. in life sciences (ex. chemistry, biochemistry, biology) with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire).
• Training in synthetic organic chemistry methods and analytical tools, in particular LCMS
• Interest in optimizing chemical reactions for use in DNA encoded library synthesis.
• High level of creativity and productivity with strong problem-solving skills.
• High level of attention to detail and good organizational skills.
• Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

• Strongly team-oriented; highly collaborative
• Hands-on approach; resourceful and open to diverse points of view

Apply Now

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

About the Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry and familiarity with the application of DNA encoded chemistry to join our Library Discovery team. You will join a group with two objectives:  1) Design and synthesize DNA encoded libraries and 2) Utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets.

You will have demonstrated experience in synthetic organic chemistry and analytical methods. Experience with DNA encoded library synthesis, parallel reaction chemistry, split/pool methods, aqueous chemistry and linker chemistry related to the synthesis of drug conjugates are all valued skills.  Understanding of the physicochemical properties that drive drug discovery are desired.  As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

• Ph.D. in synthetic organic chemistry with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire).
• Expert in synthetic organic chemistry methods and analytical tools, in particular LCMS
• High level of creativity and productivity with strong synthetic problem-solving skills.
• Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
• Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
• Familiarity with principles of combinatorial chemistry and DNA encoded library technology
• Interest in optimizing chemical reactions for use in DNA encoded library synthesis.
• Familiarity with working with large data sets and the tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

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We are seeking a highly skilled and motivated cell biologist/immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. The senior scientist/associate director is an experienced immunologist that will perform and oversee lead optimization of novel compounds and the characterization of their MOA on immune cells. The candidate must be self-driven, organized, able to manage junior scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

• D. in immunology or cancer biology with 8+ years of relevant industry experience.
• Research experience in the field of immunology with a focus on either inflammation and autoimmunity, or immunoncology.
• Strong background in small molecule drug discovery and lead optimization of molecules; experience with bi-functional degrader compounds is a plus.
• Demonstrated experience in leading small team of scientists.
• Ability to manage multiple projects simultaneously
• Hands on experience in development, optimization and execution of high-dimensional flow cytometry to phenotypically characterize immune cells, ELISA, Western and multiplexing technologies
• Excellent written and verbal communication skills across cross-functional teams
• Background in ubiquitin biology with past experience is a plus
• Ideal candidate can develop novel ideas/technologies and is eager to learn, innovate

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative; solutions and results-oriented focus
• Strong scientific curiosity and initiative; hands-on and resourceful
• Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

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The successful candidate will be a key contributor within CMC (Chemistry, Manufacturing and Control) and support the advancement of small molecule programs within the Nurix development portfolio.

In this newly-created position, the candidate will be responsible for providing hands-on support of development stage activities related to the analysis, quality control and stability testing of drug substances (DS) and drug products (DP). Reporting to the Head of CMC, candidate will also be responsible for building and growing an Analytical Development group.

Responsibilities:

• Coordinate the outsourced testing and quality control activities at CDMOs for drug substances and drug products of small molecule therapeutics.
• Manage development and validation of robust and sensitive methods for DS and DP
• Manage the identification and characterization of impurities
• Oversee transfer of analytical methods between testing laboratories and CDMOs.
• Review primary analytical data and method development reports.
• Develop method validation protocols, oversee their execution and review the reports.
• Work with DS and DP project leads to establish phase-appropriate specifications, and ensure that testing methodologies are suitable and meet the cGMP requirements.
• Manage external stability testing of DS and DP to ensure that the data support ongoing and proposed clinical studies.
• Manage supplies of reference standards, including coordinating qualification and retest
• Proactively identify gaps in analytical testing and risks and identify solutions to mitigate these risks.
• Author analytical development sections of regulatory filings.
• Work closely with stakeholders across various functional groups to successfully implement activities to advance programs in a timely manner
• Represent CMC Department in project teams and make periodic presentations to program oversight committees.
• Performs other duties as assigned

Qualifications:

• Ph.D. or Master’s degree in analytical chemistry, organic chemistry or related discipline with
• A minimum of 12 years’ experience in small-molecule analytical development
• Experience in all phases of drug development, pre-clinical to late-phase and commercial, preferably in small-pharma/biotech environment
• At least 5 years’ experience in managing outsourced testing of DS and DP
• Familiarity with operating in a GMP environment, and a thorough knowledge of FDA, ICH, USP and EP Guidelines and current best-practices in the Industry
• Hands on experience authoring CMC sections of regulatory filings (IND, IMPD, NDA)
• Excellent communication skills

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

The successful candidate will be a key contributor within CMC (Chemistry, Manufacturing and Control) and support the advancement of small molecule programs within the Nurix development portfolio.

In this newly-created position, the candidate will be responsible for providing hands-on support of development stage activities related to the process development, synthesis and manufacturing of Nurix clinical candidates. Reporting to the Head of CMC, candidate may also be responsible for building and growing the Chemical Development group.

Responsibilities:

• Develop practical and scalable synthesis routes, both internally and at CDMOs, for the manufacture of small molecule drug substances.
• Manage development of robust phase-appropriate syntheses for starting materials and intermediates
• Identify, select and manage CDMOs for process development, optimization and manufacture of cGMP DS to support clinical programs
• Oversee transfer of processes to, and between CDMOs.
• Review manufacturing records (MBR, EBR etc) and development reports.
• Prepare technical reports, publications and presentations
• Work closely with DP project leads to establish realistic project timelines and deliver adequate quantities of DS for development needs
• Proactively identify potential gaps in drug supply, related risks and identify solutions to mitigate these risks.
• Author DS sections of regulatory filings.
• Work closely with stakeholders across various functional groups to successfully implement activities to advance programs in a timely manner
• Represent CMC Department in project teams and make periodic presentations to program oversight committees.
• Performs other duties as assigned

Qualifications:

• Ph.D. or Master’s degree in organic chemistry, chemical engineering or related discipline with
• A minimum of 12 years’ experience in small-molecule chemical development
• Experience in all phases of drug development, pre-clinical to late-phase and commercial, preferably in small-pharma/biotech environment
• At least 5 years’ experience in managing CDMOs in outsourced development and manufacturing
• Familiarity with operating in a GMP environment, and a thorough knowledge of FDA, ICH Guidelines and current best-practices in the Industry
• Hands on experience authoring CMC sections of regulatory filings (IND, IMPD, NDA)
• Excellent communication skills

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology for a longer-term engagement (and possible temp-to-hire opportunity). This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly growing company.

Qualifications

• D. in immunology, cancer biology or related field with 0-2+ years of industry experience for Scientist I level position
• Research experience in the field of immunology with a focus on innate immunity
• Expertise in functional assays measuring cellular activation, cytokine release, proliferation, and killing
• Experience in high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining.
• Experience with in vivo tumor mouse models is desired but not required
• Develop novel ideas/technologies, eager to learn, innovate.
• Propose and implement resolutions to technical problems/issues.
• Work with departmental and/or cross functional peers to execute on assignments

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative; solutions and results-oriented focus
• Strong scientific curiosity and initiative; hands-on and resourceful
• Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now