Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

Nurix Therapeutics seeks an experienced Associate Director to join the Analytical Development and Quality Control group to lead IND-enabling and early phase analytical development. The Associate Director will develop analytical testing and characterization methods to evaluate drug substance and drug product attributes, identify and characterize technical risk, and collaborate toward risk mitigation strategies. The Associate Director will oversee and execute analytical development, validation, and testing operations both internally and at external CDMO/CRO partners and author relevant sections of regulatory filings.

The ideal candidate must have expertise in chromatographic method development, impurity and stability characterization, and phase-appropriate control strategy. The candidate must have a record of contribution to Phase 1 INDs, and experience in vendor oversight.

This position is based at Nurix headquarters in San Francisco, CA.

Key responsibilities include:

• Chemical and physical characterization of drug substance and drug product attributes, identification of technical risks, and collaboration on risk mitigation strategy.
• Method development for and analytical characterization of drug substances, drug products, and product stability
• Management of method development, method validation, QC testing, and reference standard management activities internally and at CDMOs/CTLs
• Management of forced degradation, long term stability, and predictive stability studies
• Contribution to OOS/OOE/OOT investigations
• Critical review of data, protocols, reports, specifications, and other documentation
• Trending stability data and establishing retest periods/shelf life using statistical methods
• Collaboration in the development of material control strategies and specifications
• Authorship of technical documents including test procedures, analytical development reports, product specifications, validation and stability protocols, COAs, stability reports, and storage statements
• Authorship of relevant IND/IMPD sections
• Collaboration toward responses to health authority requests for information
• Collaboration in multidisciplinary teams that include Chemical Development, Formulation Development, Regulatory, Quality, Supply Chain, Medicinal Chemistry, and DMPK
• Management and organization of documentation and data
• Ensuring compliance to cGMP quality standards and internal SOPs
• Travel up to 15%

Required Qualifications

• Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field)
• BS/MS degree with 12+ years or PhD with 6+ years of industrial experience in small molecule pharmaceutical development
• Expertise in HPLC method development is essential
• Additional experience in techniques such as gas chromatography, NMR, mass spectrometry, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, and/or FTIR
• Solid understanding of phase-appropriate approaches to control strategy, method validation, and retest/expiry
• Experience in analytical development and validation for drug substances, starting materials, synthetic intermediates, and solid oral drug products
• Experience in management of analytical activities at CDMOs/CROs
• Experience managing stability programs, reference standards, and retest/expiry
• Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters
• Experience in OOT/OOE/OOS management, deviation management, and change control
• Ability to critically interpret data and articulate technical concepts in multidisciplinary settings
• Ability to ensure assigned activities are completed in satisfaction of project timelines
• Strong interpersonal skills that foster collaboration within and outside of the organization
• Ability to travel domestically and internationally

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Job Summary:

As an integral member of the Clinical Development Team, this person will work closely in collaboration with the study teams providing scientific guidance and support.

The Associate Director/Director, Clinical Science will report to the VP, Head of Clinical Science or a more senior member of the Clinical Science team. They will be responsible for contributing to the strategy to advance molecules through the Nurix clinical pipeline. This role will work cross-functionally and participate in the execution of clinical studies including protocols, provide scientific expertise to support site and CRA training, data cleaning/analysis, investigator interaction and support of regulatory filings. In collaboration with the Medical Monitor and Safety team this role will be responsible for safety oversight of clinical trials.

Responsibilities:

• Participate, contribute to cross-functional clinical development teams with strong ability to work closely with all team members, address study or other program-specific questions.
• Implement Global Development Plan with strategic clinical science support.
• Authoring and/or reviewing clinical protocols.  Read and interpret scientific and medical literature for the use in clinical documents and to assist clinical team decision making.
• Prepare clinical portions of all relevant regulatory filings and meeting packages (INDs, Annual Reports, meeting requests, NDAs, etc.) for US and ex-US Health Authorities as needed.
• Integrate scientific knowledge and operational expertise to ensure translation of clinical research plans into efficiently delivered high quality studies.
• Acquire and utilize knowledge of clinical trial design and relevant disease indications to assist in study concept and protocol development. Contribute to discussions concerning scientific and procedural aspects of study design. Coordinate with departments to produce the final protocol and informed consent documents.
• Contribute and review medical data review plans, Data Safety Monitoring Board (DSMB)/Safety Review Committee (SRC) charters, and specific sections of study manuals and investigator meeting materials.
• Contribute to the development of CRFs, data edit checks, and/or patient profile design.
• Conduct ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis.
• Lead internal clinical data review meetings in conjunction with the medical monitor, if applicable
• Prepare slides as needed site calls and for dose escalation meeting, as applicable to study stage.
• Coordinate with Medical Affairs and manage external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, in conjunction with the medical monitor.
• Research and summarize published literature for continual learning and to prepare training materials for other clinical team members.
• Contribute to statistical analysis plans, table, listing, figure design and the preparation of manuscripts and other presentations of study data, as appropriate.
• Address investigator questions regarding protocol and related scientific issues and attend site initiation visits (SIVs), in coordination with the medical monitor.
• Assist in determining the activities to support a project's priorities within functional area.
• Up to 25% travel (US and International)

Basic Qualifications

Advanced degree in clinical or biological sciences (MD, PhD, or PharmD preferred) and 4+ year's (Associate Dir) or 8+ years (Director) relevant drug development experience with minimum of 3 years’ experience in oncology clinical trials.

Preferred Qualifications

• Experience in the clinical science role, in an oncology indication for first-in-human and proof of concept studies in small molecules, biologics and/or cell therapy. Registrational or Phase 3 study experience is desired.
• In depth understanding of clinical operations and translational medicine.
• Excellent interpersonal and communication skills.
• Able to translate technical concepts into accessible language and direction for the broader study team.
• Excellent attention to detail, collaboration, and initiative, with flexibility to adapt to the needs of the organization; maintain meticulous attention to project deadlines.
• Experienced in Microsoft Office (Excel, Word, PowerPoint, OneNote), and ideally also with job related programs such as Spotfire and Medidata Rave or similar.
• Strong understanding of ICH GCP, as well as general knowledge of industry practices and standards
• Commitment to patient safety and clinical compliance.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Position

Nurix is seeking a candidate for the role of Bioinformatics Scientist in the Proteomics group within Discovery Technologies and Early Research. This individual contributor role will focus on designing, implementing, and optimizing tools and workflows for proteomics data analysis, visualization, and interpretation. The candidate will creatively expand the capabilities of Nurix’s proteomics platform by integrating and developing customized tools for both global and targeted proteomics data analysis workflows. In this highly collaborative position, the candidate will work closely with proteomics team members, IT & informatics teams, biologists, and project leads, applying their tools and expertise to advance targeted protein degradation drug discovery. This candidate will also implement tools used throughout the degrader R&D life cycle to advance drug candidates alongside colleagues in Medicinal Chemistry, Biology, and Safety Assessment.

Required Skills & Experience:

Ph.D. in Biology, Chemistry, Biochemistry, Bioinformatics, or a related field with 0-3 years post-Ph.D. experience

• Expertise in:
  • Bioinformatics analysis of proteomic datasets with a focus on global proteomics workflows; familiarity with targeted proteomics is also valuable
  • Tools used for analyzing and visualizing differential expression datasets
  • Development and optimization of scripts in R and/or Python for proteomics data analysis
  • Standard statistical methods for large-scale data interpretation
• Strong experience in analyzing, condensing, and presenting complex datasets to diverse teams
• Knowledgeable in computational applications for global proteomic data
• Knowledgeable in post-translational modification (PTM) enrichment workflows

Preferred Skills & Experience

• Experience implementing or managing proteomics-related databases
• Direct experience with MS data processing tools & software
  (eg Skyline, Spectronaut/DIA-NN, MaxQuant, FragPipe)
• Knowledge of protein ubiquitylation biochemistry and pathways
• Familiarity with cloud computing platforms (e.g., AWS) for data storage and analysis
• Experience with machine learning (ML) or artificial intelligence (AI) for data analysis
• Knowledge of protein degradation pathways or prior experience in degrader drug discovery
• Strong publication record (e.g., peer-reviewed publications) and conference presentations.

Culture & Team Fit:

• Ability to work collaboratively across multiple groups within the organization
• Excellent organization and communication with effective presentation skills
• Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment
• Curious mindset with a willingness and flexibility to learn new skills
• High level of creativity and productivity with strong problem-solving skills

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix, Inc. is seeking a Clinical Trial Manager (CTM)/Sr. CTM to join the Clinical Operations team.  This individual will be responsible for management of assigned clinical trials and/or global regions. They will lead study team, vendors, clinical monitors and clinical sites throughout the life cycle of a clinical trial.

This individual will be able to manage clinical regions and/or trial(s) and have broad involvement in work central to Nurix’s strategic goals. They will apply existing technical skills, learn new skills, and play a key role in clinical development of the programs.

The CTM/Sr. CTM is responsible for the successful implementation of assigned clinical trial(s), independently, from start-up to close-out. Experience in managing cross-functional teams, vendor oversight, knowledge of applicable regulatory requirements and developing junior staff will be essential to the team's success. The CTM/Sr. CTM will represent Clinical Operations at Project team meetings and may represent Nurix at professional events.

Job Responsibilities:

• Accountable for all operational aspects of assigned clinical trial(s) and/or geographical region.
• Develop and implement clinical trial protocols, including study objectives, inclusion/exclusion criteria, and data collection procedures
• Responsible for selection of vendors/CROs and provide effective ongoing management and oversight to vendors/CROs to ensure compliance and execution of deliverables within the approved budget, study timeline, and study protocol
• Works closely with investigative site personnel, CROs, and other study vendors
• Manage relationships with site investigators and study coordinators
• Monitor and track clinical trial progress and provide status update to stakeholders
• Monitor recruitment progress and effectively address enrollment challenges
• Manage study contracting, budget, forecasting, accruals and payment process for all clinical trial vendors including investigational sites
• Collaborate with Data Management to ensure correct CRFs content is collected, prepare/implement CRF completion guidelines, and coordinate delivery of data updates, listings and study reports
• Drafts and coordinates review of relevant documents including protocols, informed consents, case report forms, monitoring plans and relevant study plans, investigator brochures and clinical study reports.
• Prepare for and manage regulatory agency audits and inspections
• Must be able to participate in cross-functional strategic initiatives under limited supervision
• Proactively identifies potential issues/risks and recommends/implements solutions
• Provides leadership to the clinical operations team working on the assigned clinical trials

Experience and Skills

• B.S./ B.A. in biological sciences with 5+ years of relevant industry experience
• Ability to travel as required for the program (25%)
• Demonstrate knowledge of FDA, EMA, ICH and GCP regulations and guidelines
• Experience managing global trials
• Experience in leading teams, including CROs, consultants and vendors
• Must display strong analytical and problem-solving skills at a project level and collaborate with colleagues to generate solutions
• Strong communication and influence skills and ability to create a clear sense of direction
• Ability to deal with time demands, incomplete information or unexpected events
• Outstanding organizational skills with the ability to work independently, multi-task and prioritize
• Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Job Summary:

Nurix Therapeutics, Inc. is seeking a Director/ Sr. Director, Regulatory Affairs (Strategy, I&I) to join the Regulatory team.  The successful candidate will be a core member of the Regulatory team and will serve as the global regulatory lead (GRL) for the immunology and inflation therapeutic area. This role will be responsible for developing the global regulatory strategy in collaboration with key internal stakeholders, as well as tactical implementation of that strategy guiding and executing compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities.

This position works cross-functionally with regulatory affairs and clinical development organizations to facilitate the completion of regulatory filing documentation according to company timelines. It also ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as required.

Responsibilities:

• Develop and implement competitive and effective global clinical & nonclinical regulatory strategies for various immunology and inflammation indications and identify potential risks and mitigation strategies associated with proposed strategies
• Work in close collaboration with the VP, Head of Regulatory Affairs and the development team leader and other cross-functional colleagues, including CROs to deliver sound, efficient development strategies and operational plans
• Represent Regulatory Affairs on assigned cross-functional development teams.
• Lead and manage the development and preparation of high-quality global submissions (including IND, CTAs, NDAs, and MAAs) for early and late-stage programs in collaboration with the regulatory and project teams to support and accelerate clinical development and regulatory approval, as applicable
• Lead communication with global Health Authorities (HA), such as FDA and EMA, including, planning and preparing for formal meetings with regulatory agencies and interpreting HA feedback from these interactions.
• Develops and executes, or oversees global regulatory strategy for long-term planning, including the potential to accommodate expedited development needs
• Anticipate issues and guide cross-functional teams on risk mitigation strategies for any development challenges Provides insight and guidance on the implementation of current regulations and assesses regulatory risk based on precedence
• Ensure adherence to current regulations associated with regulatory activities
• Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
• Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
• Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
• Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
• Participates in cross-functional process initiatives impacting regulatory submission processes and systems
• Manages consultants and contractors as needed

Experience and Skills:

• Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred Manager:
• Must have minimum of 12 years in Regulatory affairs strategy with significant experience in the immunology and inflammation therapeutic area
• Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
• Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
• Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
• Strong project management and critical thinking skills
• Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
• Excellent organizational and communication skills, both written and verbal
• Ability to work independently as well as part of a team environment
• Positive attitude, energetic and proactive
• Proven ability to manage multiple projects, identify and resolve regulatory issues
• Strong interpersonal skills and the ability to effectively work with others

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

We are seeking a highly motivated individual with a 2-4 years of lab experience with a background in purification of small molecule drug compounds by HPLC, milligram up to gram scale, to join the Analytical Chemistry group at Nurix located in The Woodlands, Texas.

This position will perform purifications of small molecule libraries by mass directed HPLC and support our early drug discovery efforts at Nurix. The candidate requires the ability to work in a fast-paced laboratory setting using state of the art analytical equipment and cloud-based data systems. This role requires hands on experience in maintenance and troubleshooting of chromatography instrumentation. This role also requires basic lab / chemical handling safety and the ability to lift 40 lbs.

The candidate should have a strong desire to learn new techniques, stay up to date with purification trends and an aptitude for robotic automation workflows. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in the dynamic team environment here at Nurix.

Required Qualifications

Minimum qualifications include a B.S. or equivalent degree in chemistry, analytical chemistry, or related field, with (2-4) years of industrial experience in analysis of small molecules, liquid chromatography, and mass spectroscopy.

Bonus Qualifications

Familiarity with Agilent ChemStation or similar chromatography software

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Company

About Nurix: Nurix Therapeutics is a cutting-edge pharmaceutical company dedicated to discovering and developing innovative therapies to treat cancer and other serious diseases. Our mission is to harness the power of protein modulation to a step change in patient care.

Position: Nurix is seeking a dedicated and detail-oriented Research Assistant to join our Chemical Development team. The successful candidate will support the development and optimization of chemical processes for the synthesis of novel therapeutic compounds. This role requires a solid foundation in organic chemistry, excellent laboratory skills, and the ability to work collaboratively in a dynamic research environment.

Key Responsibilities:

• Assist in the design and execution of characterization experiments (OVAT and/or DOE), including for the synthesis and optimization of manufacturing process
• Conduct process characterization studies for the manufacturing process
• Perform routine laboratory tasks, including preparation of reagents, purification of compounds, and maintenance of laboratory equipment.
• Conduct analytical testing using techniques such as HPLC, NMR, and mass spectrometry.
• Record and analyze experimental data, ensuring accuracy and reproducibility.
• Collaborate with team members to troubleshoot and resolve experimental challenges.
• Maintain a clean and organized laboratory workspace.
• Prepare technical reports and presentations to communicate laboratory findings.
• Work up to 80% of the time in the laboratory.

Qualifications:

• High School or GED with experience in petroleum or chemical industry; preferably B.S. or M.S. in Chemistry, Chemical Engineering, or a related field.
• Hands-on experience in a laboratory setting, preferably in organic synthesis or chemical development.
• Familiarity with common analytical techniques (e.g., HPLC, NMR, mass spectrometry).
• Strong attention to detail and excellent organizational skills.
• Ability to work independently and as part of a team.
• Good written and verbal communication skills.
• Proficiency in data analysis and interpretation.
• Proficiency in the use of scientific databases such as Scifinder and Reaxys.

Bonus Qualifications:

• Experience in the pharmaceutical industry.
• Hands-on experience of conducting processes on 5-20 L scale.
• Experience in setting up and maintaining 1-20 L jacketed reaction vessels
• Experience in the use of Dynochem for process modeling.
• Experience in the use of Design of Experiment software such as JMP and Design Expert

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age or genetics. In addition to federal law requirements, Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Nurix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, or veteran status. Improper interference with the ability of Nurix’s employees to perform their job duties may result in discipline up to and including discharge.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Position

We are seeking a talented and highly motivated scientist with a strong background and hands-on experience in bioconjugation to join our Discovery Chemistry team. In this laboratory-based position, you will play a pivotal role in the development of cutting-edge Degrader-Antibody Conjugates (DACs) across various therapeutic areas. The successful candidate will have the opportunity to directly contribute to the following key platform operations:

• Develop, optimize and implement high-throughput bioconjugation processes through the application of established and state-of-the-art technologies
• Execute high-throughput preparation of novel antibody drug conjugates at milligram scale
• Contribute to the design and synthesis of linkers and linker-payloads to enhance conjugate properties 
• Prepare, purity and characterize bioconjugates to support in-vitro and in-vivo studies
• Contribute to the collaborative efforts focused on the development and optimization of bioanalytical protocols to evaluate critical quality attributes of DACs 
• Engage in cross-functional discussions and contribute to scientific strategies and team goals focused on advancing Nurix’s Degrader-Antibody Conjugate (DAC) discovery programs
• Prepare reports and present data at internal group meetings

Education and Experience

• Ph.D. in Organic Chemistry, Chemical Biology, Biochemistry, or related field with up to 4 years relevant experience OR MS with 6+ years relevant experience, OR BS or equivalent with 10+ years relevant experience
• Experience with high-throughput automated workflows to produce bioconjugates
• Hands-on laboratory experience in carrying out diverse conjugation chemistry protocols, linker-payload synthesis and related processors to produce high-quality drug conjugates
• Familiar with the general workflow operations, instrumentation and practices used for the generation of antibody-drug conjugates
• Experience characterizing and purifying bioconjugates using common analytical tools
• Experience working in the drug discovery chemistry field – linker design, synthesis, and SAR based property optimization of small molecules
• Established track record of conference presentations and peer-reviewed publications in the areas of antibody drug conjugation and organic synthesis
• Strong written and verbal communication skills

Added Quantifications

• Postdoctoral or industrial work experience in the bioconjugation field
• Experience working in Antibody-Drug Conjugate (ADC)- or Degrader-Antibody Conjugate (DAC)- based drug discovery programs
• Experience working with bioanalytical tools such as hydrophobic interaction chromatography (HIC), preparative-scale size exclusion chromatography (SEC), liquid chromatography-mass spectrometry (LC-MS), ion-exchange (IEX), and reversed phase (RP)-HPLC, Nuclear Magnetic Resonance (NMR) Spectroscopy
• Experience carrying our assays to evaluate in-vitro stability of ADC and payloads such as Cathepsin B, esterase activity and free drug analysis

Fit with Nurix Culture and Values

• Strong team orientation and highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Company

Nurix Therapeutics (www.nurixtx.com) is a public biopharmaceutical company developing novel small molecule immune modulators for the treatment of cancer and autoimmune diseases. Based on the successful progress of our R&D platform, including expertise in medicinal chemistry, immune cell biology and in vivo pharmacology, Nurix is advancing multiple programs to the clinical stage. The company’s lead drugs are a novel protein degradation agent for blood borne tumors and a mechanistically novel oral, immunomodulatory agent for solid tumors.

The candidate will be responsible for chemical development-related activities across the portfolio including process development and manufacture of regulatory starting materials (RSMs) and supporting production of Drug Substance (DS) for clinical trial materials, and establishment of associated control strategy for RSMs and DS to support CMC regulatory documents. The ideal candidate will be a highly motivated chemist with experience and interest in working in a small, entrepreneurial environment with broad responsibilities and opportunities.

Principal Duties and Responsibilities

• Development of robust, scalable, and cost-effective phase-appropriate manufacturing process that meet or exceed quality and regulatory requirements
• Work up to 50% of the time in the lab to support process route development and ongoing production campaigns
• Responsible for supporting RSMs and DS manufacturing related activities, including scale-up of compounds to support internal and external drug development
• Author tech transfer documents and work with CROs/CDMOs to effectively and efficiently reproduce chemistry at various sites
• Support phase-appropriate process characterization, identify critical quality attributes, and implement controls, including selection and justification of RSMs to ensure that all CROs and CMOs are using systems and processes in compliance with all relevant regulatory standards and to ensure consistency of DS quality
• Prepare, review, or edit technical reports, protocols, cGMP batch records, CMC regulatory submissions and Quality documents
• Collaborate with cross-functional teams, including analytical chemistry, formulation, quality and regulatory to support drug development programs
• Travel up to 25%

Skills and Background

• PhD with 2+ years of experience or MS with 5+ years of experience; advanced degree in Organic Chemistry, Chemical Engineering, Pharmaceutical Chemistry, Pharmaceutics, Pharmaceutical Science, or related scientific discipline,
• 1-3 years relevant experience in a pharmaceutical or biotechnology CMC/cGMP environment preferred
• Hands-on experience in multi-steps organic synthesis. Familiarity with common analytical techniques (e.g., HPLC, NMR, mass spectrometry)
• Strong working knowledge of synthetic organic chemistry and the ability to leverage it toward route development and rapid synthetic triage
• Experience leveraging US and International CRO/CMOs for the manufacture of RSMs and DS to meet aggressive timelines
• Excellent problem-solving skills and the ability to identify, resolve critical issues, and work independently
• Experience implementing technical, strategic, and operational plans
• Excellent written and verbal communication skills, exceptional interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators)
• Strongly team oriented

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age or genetics. In addition to federal law requirements, Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Nurix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, or veteran status. Improper interference with the ability of Nurix’s employees to perform their job duties may result in discipline up to and including discharge.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

About Nurix: Nurix Therapeutics is a cutting-edge pharmaceutical company dedicated to discovering and developing innovative therapies to treat cancer and other serious diseases. Our mission is to harness the power of protein modulation to transform patient care.

The Position: Nurix is seeking a highly motivated and experienced Senior Scientist to join our Chemical Development team. The successful candidate will play a critical role in the development and optimization of chemical processes for the synthesis of novel therapeutic compounds. This position requires a deep understanding of organic chemistry, process development, and scale-up, as well as strong problem-solving skills and the ability to work collaboratively in a fast-paced environment.

Key Responsibilities:

• Characterize impurity profile of the manufacturing process and conduct impurity fate and purge experiments
• Design and conduct process characterization studies (OVAT and/or DOE) for the manufacturing process
• Mentor and provide guidance to junior scientists and research associates.
• Design and develop robust and scalable chemical processes for the synthesis of small molecule therapeutics.
• Optimize reaction conditions and improve process efficiencies to ensure high yield and purity.
• Collaborate with cross-functional teams, including analytical chemistry, formulation, quality and regulatory to support drug development programs.
• Troubleshoot and resolve complex synthetic and process-related challenges.
• Author tech transfer documents and work with CROs/CDMOs to effectively and efficiently reproduce chemistry at various sites.
• Prepare and review technical reports, protocols, and assist in the preparation of regulatory documentation, INDs, CTAs, NDAs and MAAs.
• Present findings and updates to internal and external stakeholders.
• Work up to 60% of the time in the laboratory.

Qualifications:

• Ph.D. in Organic Chemistry, Chemical Engineering, or a related field with 3+ years of relevant industry experience, or M.S. with 5+ years of experience.
• Proven track record in chemical process development and scale-up.
• Demonstrated experience with NDA supportive characterization studies (OVAT and/or DOE) and identification of critical process parameters (CPPs) for process validation
• Strong knowledge of modern synthetic organic chemistry techniques and methodologies.
• Familiarity with analytical techniques such as HPLC, NMR, and mass spectrometry.
• Experience with process optimization, including reaction kinetics, thermodynamics, and mechanistic studies.
• Familiarity with regulatory requirements and guidelines for pharmaceutical development.
• Excellent problem-solving skills and the ability to work independently and as part of a team.
• Strong written and verbal communication skills.
• Ability to manage multiple projects and prioritize tasks effectively.

Bonus Qualifications:

• Experience in the pharmaceutical industry, particularly in late stage process development.
• Hands-on experience of scaling up processes in 5-20 L jacketed reaction vessels.
• Experience in setting up and maintaining 1-20 L jacketed reaction vessels and auxiliary systems.
• Experience in the use of Dynochem for process modeling.
• Experience in the use of Design of Experiment software such as JMP and/or Design Expert

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age or genetics. In addition to federal law requirements, Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Nurix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, or veteran status. Improper interference with the ability of Nurix’s employees to perform their job duties may result in discipline up to and including discharge.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Position:

We are looking for an Intellectual Property (IP) Attorney with a strong chemistry and pharmaceutical background to head Nurix’s IP function. The successful candidate will be responsible for managing, protecting, and enforcing the company’s intellectual property portfolio, which includes patents, trademarks, and trade secrets. The ideal candidate will have significant experience in both law firm and in-house settings, strategic pharmaceutical portfolio management, and IP litigation.

Key Responsibilities:

• Patent Strategy and Management:
  • Oversee the development, prosecution, and management of the company's patent portfolio (domestic and international).
  • Work closely with research and development (R&D) teams to identify and protect patentable inventions.
  • Advise on patentability, freedom-to-operate, and landscape analysis.
  • Collaborate with outside counsel to manage patent filings and ensure timely and strategic prosecution of patent applications.
    
    
• Trademark and Trade Secret Protection:
  • Advise on trademark strategy, including registration, protection, and enforcement of trademarks.
  • Develop and implement policies for the protection of trade secrets and confidential information.
    
    
• IP Litigation and Disputes:
  • Provide counsel on IP disputes, including patent infringement, litigation, and settlement negotiations.
  • Manage relationships with outside litigation counsel and coordinate defense or enforcement of the company’s IP rights.
    
    
• Licensing and Agreements:
  • Negotiate and draft licensing agreements, joint ventures, and other collaborations related to IP.
  • Provide legal support for agreements involving intellectual property, including research and development agreements, patent assignments, and material transfer agreements.
    
    
• Cross-Functional Collaboration:
  • Work closely with internal teams, including R&D, business development, regulatory affairs, and commercial teams, to align IP strategy with business objectives.
  • Provide training and legal guidance to other departments on IP-related matters.

Qualifications:

• Education:
  • Juris Doctor (JD) from an accredited law school.
  • Admission to practice law in California.
    
    
• Experience:
  • 10+ years of experience as an IP attorney, preferably with a biopharmaceutical focus.
  • In-depth knowledge of patent law, trademark law, trade secret protection, and related litigation.
  • Proven experience managing complex patent portfolios and providing strategic IP advice to R&D teams.
  • Experience negotiating and drafting IP licensing and other commercialization agreements.
    
    
• Skills and Abilities:
  • Strong analytical skills and the ability to interpret complex scientific and legal information.
  • Excellent written and verbal communication skills.
  • Ability to work independently and collaboratively within cross-functional teams.
  • High level of professional integrity and attention to detail.
  • Strong problem-solving and negotiation skills.

What We Offer:

• Competitive salary and benefits package.
• Supportive leadership and a collaborative team culture.
• Opportunity to work on cutting-edge pharmaceutical innovations and IP strategies.
• Career growth and professional development opportunities in a rapidly expanding company.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

Nurix Therapeutics seeks an experienced Senior Manager to join the Analytical Development and Quality Control group. The Senior Manager will oversee daily lab operations, train/mentor/supervise lab personnel, execute method development and routine/nonroutine analysis, and manage purchasing/installation/maintenance of instrumentation, equipment and consumables.

This position is onsite in The Woodlands, Texas.

Key responsibilities include:

• Oversight of analytical chemistry lab operations
• Training, mentorship, task management, and supervision of lab personnel
• Establishment of workflows for sample receipt, analysis, data reporting, and data management
• Routine and non-routine chromatographic and solid state analysis to support chemical process development
• Method development and troubleshooting for analytical characterization of drug substances, raw materials, and synthetic intermediates
• Design and execution of forced degradation and predictive stability studies
• Instrument and equipment management to include:
  • Oversight of instrument installation and operational qualification
  • Management of service contracts, periodic maintenance, and lab consumables
  • Instrument troubleshooting and repair as needed
• Critical review of data, reports, specifications, and other documentation
• Collaboration in the development of material control strategies and specifications
• Authorship of technical documents including analytical development reports, stability reports, and storage statements
• Collaboration in multidisciplinary teams
• Management and organization of documentation and data
• Ensuring compliance with internal SOPs and lab safety procedures
• Travel up to 5%

Qualifications

• Advanced degree in a relevant scientific discipline (Chemistry, Pharmaceutics, Chemical Engineering or related field)
• BS/MS degree with 8+ years or PhD with 4+ years of industrial experience in small molecule analytical lab operations
• 2+ years of experience managing direct reports
• Expertise in liquid chromatography and gas chromatography method development, operation, maintenance, and troubleshooting is essential
• Experience in mass spectrometry, solid state characterization, and predictive stability studies is desired
• Familiarity with ICH guidelines and cGMPs
• Ability to critically interpret data and articulate technical concepts in multidisciplinary settings
• Ability to ensure assigned activities are completed in satisfaction of project timelines
• Strong interpersonal skills that foster collaboration within and outside of the organization
• Ability to travel domestically and internationally

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Senior Manager /Associate Director of Biostatistics

Nurix has a place for an extraordinary, highly motivated, self-starter and accomplished Sr. Manager/Associate Director of Biostatistics to become a part of growing biometrics organization.

Position

The Sr. Manager/Associate Director of Biostatistics will provide subject matter expertise for planning and be accountable for the clinical study related deliverables for Nurix clinical development programs. The successful candidate will have responsibility for strategy and operational activities, as well as assisting the Head of Biostatistics in the development and implementation of departmental policies, operational guidelines, and administrative structure. The successful candidate will also serve as senior specialist within Clinical Development and within the field of clinical trial design, data science, statistical methodology and application. The candidate should have a successful and progressive track record in leading teams and effectively structuring a function to manage the anticipated growth in the product pipeline. The successful candidate must also possess excellent communication skills to interface with senior leadership on behalf of the department and work closely with medical study directors to provide and receive direction on clinical programs and can influence the clinical teams.

Additional key representative responsibilities will include, but not necessarily be limited to, the following:

Job Responsibilities

• Provide statistical expertise to support Global Clinical Development in the organization
• Take analytic leadership role in developing efficient clinical development programs and guide clinical development strategy from an analytical focus
• Support the development and implementation of innovative strategies and technologies for biostatistics
• Proficiency and/or thought leadership in novel methodologies such as Bayesian methodologies, adaptive design, simulation, and statistical modeling
• Stay abreast of emerging technologies and concepts related to applied statistical methodology
• Direct the statistical design, conduct, and analysis of clinical trials in all phases
• Review protocols and case report forms for soundness of trial design
• Author statistical analysis plans for all phases of a trial
• Communicate and collaborate effectively with other clinical development functions (including but not limited to clinical development, clinical operations, translational medicine, safety and pharmacovigilance)
• Perform and/or review the analysis and interpretation of clinical study results, and collaborate with clinical team to produce interim reports, final reports, and publications
• Direct the development, validation and summary of integrated safety and efficacy summary documents for submissions
• Support pre-clinical and research teams on the experimental design, data analysis and statistical modeling activities
• Evaluate and manage contract research organizations and other vendors, including scope-of-work, timelines, deliverables, and budgets
• Ensures quality of deliverables by consistently applying analysis and reporting standards, and driving compliance with regulatory requirements, corporate and departmental SOPs and work practices
• Develop and implement department standards and practices to ensure statistical integrity of project deliverables

Qualifications

• Advanced degree in statistics, biostatistics, mathematics, computer science or equivalent experience
• Minimum of 6 years (for Sr. Manager or 8 years for Assoc. Director) of progressive experience leading as study/program biostatistician in biotech/pharmaceutical industry
• Experience in all phases of oncology clinical development
• Experience in managing technical professionals in a regulated environment is desirable
• Experience of mentoring and maintaining statistics group in multiple clinical development programs simultaneously
• Significant knowledge of the drug development process, clinical trial methodology, statistics, and relevant regulatory requirements for drug approval
• Experience building and utilizing innovative dynamic reporting and data monitoring tools (such as Spotfire, Tableau, R-shiny)
• Demonstrated ability to operate and lead in a dynamic organization, build successful working relationships and effective stakeholder management in an environment that requires diverse educational and functional expertise.
• Extensive experience working with external vendors, including but not limited to acquisition, contracting, evaluation of vendor’s capabilities and deliverables
• Extensive knowledge of statistical software (SAS, R, EAST, etc.) and general computing techniques in addition to knowledge of R or other statistical software packages
• Able to organize multiple work assignments and establish priorities
• Excellent verbal and written communications skills; able to communicate proactively and effectively

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position Description

Nurix is seeking a Senior/Principal Scientist, Pharmaceutical Development to provide scientific, technical, and hands-on leadership of small molecule oral solid formulation development for pre-clinical through Phase 1 clinical trial stages. Responsibilities will include but are not limited to:

• Lead small molecule preclinical and clinical formulation development and characterization in support of internal Nurix development programs
• Manage outsourced development projects and manufacturing including timeline and resource planning, to ensure milestones and deliverables are met efficiently
• Partner with Nurix Chemical Development and Analytical Development to identify optimal drug substance properties and control strategies
• Oversee preparation and characterization of pre-clinical drug products for in-house and partner with Global Supply Chain Operations for outsourced studies and clinical manufacturing
• Serve as drug product SME for cross-functional project teams
• Author and review relevant sections of regulatory filings, technical protocols, reports, ect.
• Manage and mentor research associates
• Contribute to internal and external presentations and publications.

Required Qualifications

• In-depth knowledge and demonstrated expertise and accomplishment in oral solid dose form, characterization, manufacturing process development, and Phase I clinical manufacturing
• Significant experience with design, scale-up, and outsourced manufacture of amorphous solid dispersion-based formulations design (spray drying, hot melt extrusion, tableting and encapsulation); experience with other enabled oral formulations a plus
• Prior experience in formulation of targeted protein degrader molecules (aka CTMs, degraders, PROTACS) a plus
• Thorough understanding of analytical techniques used for pre-formulation and characterization of oral solid dose forms including HPLC, LC-MS, XRPD, DSC, Dissolution, and KF
• Excellent technical problem solving and troubleshooting abilities
• Excellent written and oral communications skills
• PhD (preferred) or MS in chemistry, pharmaceutics, engineering, or related field with at least 7 years relevant industrial experience
• Ability to travel up to 25% of time

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

The Company

Nurix is a biopharmaceutical company committed to bringing novel, first-in-class therapies to patients. We are a leader in discovering and developing a new class of drugs designed to modulate protein levels in cells through E3 ubiquitin ligase activity within the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein homeostasis – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. Nurix’s scientific team has established an innovative drug discovery platform aimed at identifying novel therapeutics that either modulate E3 ligase function directly or harness it to direct the fate of other disease-relevant target proteins.

Nurix was founded by a team of internationally renowned experts in the fields of E3 ubiquitin ligase regulation and structure. Since its incorporation, Nurix has built a seasoned team of leaders with wide-ranging backgrounds in small molecule drug development and cancer therapy. Through its leadership in Targeted Protein Modulation and its powerful proprietary DELigase platform, Nurix has attracted industry-leading partners, including its current drug discovery collaborations with Gilead Sciences, Sanofi, and Pfizer. Nurix is based in San Francisco’s biotechnology hub, Mission Bay – where academia and industry come together for cutting-edge life-saving research.

The Position

We are seeking a motivated and highly skilled Senior Research Associate or Scientist I in our Preclinical Pharmacology group to support the development of novel therapeutics for cancer and inflammatory disorders. The ideal candidate will have expertise in pharmacological profiling of small molecule drugs, xenograft and syngeneic tumor models, mammalian cell and molecular biology, and mechanisms of disease in oncology and inflammation. Specific responsibilities for this role include the design, execution and analysis of in vitro and in vivo experiments, assay development for in vitro and in vivo PK/PD profiling, and presentation of data at project team meetings. The candidate will be expected to work independently and collaboratively across multiple Nurix groups (Discovery Biology, Medicinal Chemistry, DMPK), and to generate high quality, impactful results in an exciting and fast-paced research environment.

Qualifications

• Ph.D. in pharmacology, cancer biology, immunology or related field with 1 year of relevant post-doctoral or industry experience, or M.S. with 5 years of relevant experience, or B.S. with 10 years of relevant experience
• Expertise in oncology, immunology, and in vivo models of cancer and inflammatory disease
• Expertise in small molecule drug development and PK/PD assay technologies
• Expertise in hit-to-lead optimization and establishment of PK/PD relationships
• Expertise in multi-color flow cytometry to profile immune cell populations in primary tissues and immortalized cell lines
• Excellent communication, organization and time-management skills
• Excellent ability to work collaboratively and efficiently with other team members across disciplines
• Excellent ability to address complex scientific problems using hypothesis-driven and methodical approaches

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Position Description

Nurix is seeking an experienced, independent, and highly motivated individual to support the late-stage drug product development through approval of NX-5948 and the expansion of the Nurix pipeline. This Senior Scientist, Pharmaceutical Development will work closely with the CMC team and colleagues in cross functional departments to manage development and production activities at CROs and CDMOs. Position reports to Director, Pharmaceutical Development.

Responsibilities will include but are not limited to:

• Oversee technical activities at CDMOs for development of solid oral drug products, including tech transfer, process development, CTM production, troubleshooting, QbD and PAR studies, registration batch production, and process validation.
• Effect phase appropriate refinements of manufacturing processes, conduct robustness studies, and identify critical quality parameters to develop and streamline a manufacturing process that is scalable for potential commercialization. Conduct risk assessments/FMEAs through process development and pre-validation.
• Establish measures and metrics to define manufacturing performance and provide recommendations to management to optimize operations.
• Works collaboratively and transparently with Quality Assurance and Regulatory Affairs to ensure a high-quality level of cGMP manufacturing excellence.
• Review and approve master batch records and validation protocols/reports required for drug product manufacturing.
• Author and review technical protocols, development reports, and Drug Product CMC sections for regulatory submissions (including INDs, IMPDs, NDAs, briefing packages or other regulatory dossiers).
• On-site presence at CDMOs during critical meetings and manufacturing.

Required Qualifications

• PhD in chemistry, pharmaceutics, engineering, or related field with at least 5 years relevant industrial experience or MS with at least 8 years working experience in formulation, chemical engineering, or related area.
• Minimum of 3 years' experience in managing outsourced development activities.
• In-depth knowledge and demonstrated expertise and accomplishment in small molecule oral solid dose form (capsules and tablets) characterization and manufacturing process development; experience with amorphous solid dispersion-based formulations a plus
• Strong knowledge of pharmaceutical and engineering principles in the solid dosage form development for both clinical and commercial scales including cGMP manufacturing.
• Knowledgeable with Registration and Process Validation campaigns including designing and executing FMEA/DOE. Also, experience with product readiness for launch.
• Familiar with statistics software (Minitab or JMP), familiar with DOE design and data analysis
• Excellent written and oral communications skills
• Ability to travel up to 25% of time

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

JOB DESCRIPTION: Sr Scientist/Principal Scientist, Chemical Development – Nurix Therapeutics

Nurix Therapeutics (www.nurixtx.com) is a public biopharmaceutical company developing novel small molecule immune modulators for the treatment of cancer and autoimmune diseases. Based on the successful progress of our R&D platform, including expertise in medicinal chemistry, immune cell biology and in vivo pharmacology, Nurix is advancing multiple programs to the clinical stage. The company’s lead drugs are a novel protein degradation agent for blood borne tumors and a mechanistically novel oral, immunomodulatory agent for solid tumors.

The candidate will be responsible for chemical development-related activities across the portfolio including process development and manufacture of regulatory starting materials (RSMs) and support production of Drug Substance (DS) for clinical trial materials, and establishment of associated Control Strategy for RSMs and DS to support IND/NDA filing and commercial manufacturing. The ideal candidate will be a highly motivated chemist with experience and interest in working in a small, entrepreneurial environment with broad responsibilities and opportunities.

Principal Duties and Responsibilities

• Development of robust, scalable, and cost-effective phase-appropriate manufacturing process that meet or exceed quality and regulatory requirements
• Work up to 50% of the time in the lab to support process route development and ongoing production campaigns.
• Author technical reports to support regulatory filings
• Responsible for supporting RSMs and DS manufacturing related activities, including scale-up of candidate compounds to support candidate selection during drug discovery, from preclinical development through commercialization
• Support phase-appropriate process characterization, identify critical quality attributes, and implement controls, including selection and justification of RSMs to ensure that all CROs and CMOs are using systems and processes in compliance with all relevant regulatory standards and to ensure consistency of DS quality
• Support the characterization of late phase programs according to the principles of QbD (mapping studies, DOEs) to identify critical quality attributes and critical process parameters (including edge of failure and proven acceptable ranges) and implement DS Control Strategy to support NDAs/MAAs
• Support management of RSMs and DS supply chain and logistics in support of demand for clinical studies and commercial products
• Support process validation programs to support commercialization
• Prepare and/or review CMC sections of INDs, CTAs, NDAs, MAAs and other regulatory submissions; represent the company as the DS expert before U.S. and European regulatory authorities
• Prepare, review, or edit cGMP batch records, CMC regulatory and Quality documents
• Travel up to 25%

Skills and Background 

• PhD with 5-7 years of experience or MS with 10+ years of experience; advanced degree in Organic Chemistry, Chemical Engineering, Pharmaceutical Chemistry, Pharmaceutics, Pharmaceutical Science, or related scientific discipline,
• 3-5 years relevant experience in a pharmaceutical or biotechnology CMC/cGMP environment preferred
• Experience leveraging US and International CRO/CMOs for the manufacture of RSMs and DS to meet aggressive timelines
• Experienced with cGMP manufacturing and IND/IMPD and NDA/MAA filings thorough knowledge of relevant FDA and EMEA regulations
• Strong working knowledge of synthetic organic chemistry and the ability to leverage it toward route development and rapid synthetic triage
• Experience analyzing experimental and analytical data
• Able to identify and resolve critical issues
• Experience implementing technical, strategic, and operational plans
• Excellent written and verbal communication skills, exceptional interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators)
• Strongly team oriented

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age or genetics. In addition to federal law requirements, Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Nurix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, or veteran status. Improper interference with the ability of Nurix’s employees to perform their job duties may result in discipline up to and including discharge.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).