Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

Nurix Therapeutics seeks an experienced Associate Director to join the Analytical Development and Quality Control group to lead IND-enabling and early phase analytical development. The Associate Director will develop analytical testing and characterization methods to evaluate drug substance and drug product attributes, identify and characterize technical risk, and collaborate toward risk mitigation strategies. The Associate Director will oversee and execute analytical development, validation, and testing operations both internally and at external CDMO/CRO partners and author relevant sections of regulatory filings.

The ideal candidate must have expertise in chromatographic method development, impurity and stability characterization, and phase-appropriate control strategy. The candidate must have a record of contribution to Phase 1 INDs, and experience in vendor oversight.

This position is based at Nurix headquarters in San Francisco, CA.

Key responsibilities include:

• Chemical and physical characterization of drug substance and drug product attributes, identification of technical risks, and collaboration on risk mitigation strategy.
• Method development for and analytical characterization of drug substances, drug products, and product stability
• Management of method development, method validation, QC testing, and reference standard management activities internally and at CDMOs/CTLs
• Management of forced degradation, long term stability, and predictive stability studies
• Contribution to OOS/OOE/OOT investigations
• Critical review of data, protocols, reports, specifications, and other documentation
• Trending stability data and establishing retest periods/shelf life using statistical methods
• Collaboration in the development of material control strategies and specifications
• Authorship of technical documents including test procedures, analytical development reports, product specifications, validation and stability protocols, COAs, stability reports, and storage statements
• Authorship of relevant IND/IMPD sections
• Collaboration toward responses to health authority requests for information
• Collaboration in multidisciplinary teams that include Chemical Development, Formulation Development, Regulatory, Quality, Supply Chain, Medicinal Chemistry, and DMPK
• Management and organization of documentation and data
• Ensuring compliance to cGMP quality standards and internal SOPs
• Travel up to 15%

Required Qualifications

• Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field)
• BS/MS degree with 12+ years or PhD with 6+ years of industrial experience in small molecule pharmaceutical development
• Expertise in HPLC method development is essential
• Additional experience in techniques such as gas chromatography, NMR, mass spectrometry, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, and/or FTIR
• Solid understanding of phase-appropriate approaches to control strategy, method validation, and retest/expiry
• Experience in analytical development and validation for drug substances, starting materials, synthetic intermediates, and solid oral drug products
• Experience in management of analytical activities at CDMOs/CROs
• Experience managing stability programs, reference standards, and retest/expiry
• Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters
• Experience in OOT/OOE/OOS management, deviation management, and change control
• Ability to critically interpret data and articulate technical concepts in multidisciplinary settings
• Ability to ensure assigned activities are completed in satisfaction of project timelines
• Strong interpersonal skills that foster collaboration within and outside of the organization
• Ability to travel domestically and internationally

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics (www.nurixtx.com) is a public biopharmaceutical company developing novel small molecule immune modulators for the treatment of cancer and autoimmune diseases. Based on the successful progress of our R&D platform, including expertise in medicinal chemistry, immune cell biology and in vivo pharmacology, Nurix is advancing multiple programs to the clinical stage. The company’s lead drugs are a novel protein degradation agent for blood borne tumors and a mechanistically novel oral, immunomodulatory agent for solid tumors.

The candidate will be responsible for chemical development-related activities across the portfolio including process development and manufacture of active pharmaceutical ingredients (APIs) to support production of clinical trial materials, process characterization and establishment of associated Control Strategy to support NDA/MAA filing and commercial manufacturing. The ideal candidate will be a highly motivated leader with experience and interest in working in a small, entrepreneurial environment with broad responsibilities and opportunities. 

Principal Duties and Responsibilities 
• Responsible for regulatory starting materials (RSMs) and Drug Substance (DS) cGMP manufacturing related activities, including scale-up of candidate compounds to support candidate selection during drug discovery, from preclinical development through commercialization
• Identification, selection, and management of Contract Manufacturing Organizations (CMOs) for process optimization and cGMP manufacture of DS in support of ongoing clinical programs 
• Delivery of robust, scalable, and cost-effective phase-appropriate manufacturing and DS inventory that meet or exceed quality and regulatory requirements
• Implement phase-appropriate process characterization, identify critical quality attributes, and implement controls, including selection and justification of regulatory starting materials (RSMs) to ensure that all CROs and CMOs are using systems and processes in compliance with all relevant regulatory standards and to ensure consistency of DS quality
• Lead the characterization of late phase programs according to the principles of QbD (mapping studies, DOEs) to identify critical quality attributes and critical process parameters (including edge of failure and proven acceptable ranges) and implement DS Control Strategy to support NDAs/MAAs
• Support management of RSMs and DS supply chain and logistics in support of demand for clinical studies and commercial products 
• Develop and execute plans for the primary stability registration and validation batches of DS as required by cGMP, ICH (International Conference of Harmonization) and FDA regulations 
• Lead process validation programs to support commercialization 
• Prepare and/or review CMC sections of INDs, CTAs, NDAs, MAAs and other regulatory submissions; represent the company as the DS expert before U.S. and European regulatory authorities 
• Prepare, review, or approve cGMP batch records, CMC regulatory and Quality documents 
• Prepare technical reports, publications, and oral presentations 

Skills and Background 
• PhD or MS with 12+ years of experience; advanced degree in Chemical Engineering, Pharmaceutical Chemistry, Organic Chemistry, Pharmaceutics, Pharmaceutical Science, or related scientific discipline, with 4 years of management experience 
• At least 10 years relevant experience in a pharmaceutical or biotechnology CMC/cGMP environment 
• Substantial experience leveraging US and International CRO/CMOs for the manufacture of cGMP DS to meet aggressive timelines
• Substantial experience with projects in late-stage development 
• Substantial experienced with cGMP manufacturing and IND/IMPD and NDA/MAA filings; thorough knowledge of relevant FDA and EMEA regulations 
• Experience in supply chain management. 
• Able to identify and resolve critical issues 
• Work well in a collaborative environment with analytical, formulation, quality and regulatory teams
• Experience implementing technical, strategic, and operational plans 
• Excellent written and verbal communication skills, exceptional interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators) 
• Qualities of servant leadership and self-awareness required 
• Travel up to 50% 

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age or genetics. In addition to federal law requirements, Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Nurix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, or veteran status. Improper interference with the ability of Nurix’s employees to perform their job duties may result in discipline up to and including discharge.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Position

The Senior Scientist/Associate Director of Clinical Biomarkers will play a pivotal role in advancing biomarker strategies to support the clinical development of Nurix’s innovative therapies targeting protein homeostasis. As a leader in the Clinical Biomarkers team, the successful candidate will collaborate across research, clinical development, and external partnerships to drive the biomarker strategy for early phase clinical trials, with a strong emphasis on immune-mediated and inflammatory diseases. This role involves leading the design, execution, and interpretation of biomarker assays, contributing to patient selection, pharmacodynamic assessments, and the elucidation of drug mechanisms of action in immune-mediated and inflammatory disease.

Specific responsibilities include:

• Lead the development, validation, and execution of clinical biomarker strategies to inform patient stratification, response prediction, and resistance mechanisms across Nurix’s clinical programs.
• Leverage deep expertise in immunology, inflammation, and autoimmune diseases, to design and interpret both preclinical and clinical biomarker studies.
• Oversee biomarker assay development, including assay qualification and execution on diverse platforms, to support pharmacodynamic and predictive biomarker analysis in clinical trials.
• Lead the evaluation and implementation of novel biomarker assays in both nonclinical models and patient-derived samples, ensuring alignment with clinical trial objectives.
• Collaborate closely with multidisciplinary teams, including research scientists, clinical development, external collaborators, and contract research organizations (CROs), to ensure seamless integration of biomarker data into clinical development plans.
• Provide scientific and strategic input into clinical trial designs, ensuring biomarker data are effectively utilized to guide therapeutic decisions and optimize patient outcomes.
• Mentor and manage junior scientists, fostering a collaborative and innovative research environment.
• Demonstrate strong motivation, creativity, and teamwork, with excellent time management and organizational skills.

Education and Skills Requirements:

• Advanced degree (M.S, Ph.D. preferred) with 4+ years of experience in a relevant scientific area within the pharmaceutical or biotech industry; candidates with a strong translational biomarker background in inflammation, immuno-oncology, and hematology are preferred.
• Proven expertise in the development, qualification, and implementation of clinical biomarker assays, particularly in the areas of inflammation, immuno-oncology, cancer biology, or related therapeutic areas.
• Extensive technical experience across diverse platforms, including flow cytometry, molecular biology, proteomics, and tissue-based assays; hands-on experience with clinical samples is a plus.
• Demonstrated leadership in cross-functional teams, with a track record of integrating biomarker data to influence clinical decision-making.
• Strong organizational and project management skills, with the ability to lead multiple projects simultaneously in a fast-paced environment.
• Excellent communication and interpersonal skills, with the ability to present complex biomarker data to both scientific and clinical audiences, as well as external stakeholders.
• Innovative mindset with a proactive approach to problem-solving and a strong motivation to drive scientific excellence in biomarker research.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

The Associate Director in the Clinical Pharmacology group will contribute to efforts across early and late-stage programs. As an early member of the Clinical Pharmacology group, you will have an opportunity to influence the direction of the clinical pharmacology group at Nurix. The successful applicant shall be proficient in developing and executing clinical pharmacology strategy including PK/PD modeling and simulation activities, such as but not limited to population PK/PD modeling, physiologically-based PK (PBPK) modeling and quantitative systems pharmacology (QSP) modeling. This includes data analysis and interpretation and presentation of findings to optimize doses, dosage regimens and study designs. The candidate will also author and review clinical pharmacology documents for submission and/or response to regulatory agencies. The candidate will be influential across multiple functions including individual contributors, development program teams, and the executive team.

Responsibilities

• Develop clinical pharmacology development plans, timelines and prioritization of studies
• Oversee and contribute to clinical pharmacology sections of clinical study protocols, SAPs, CSRs, stand-alone PK/PD reports, Clinical development plans
• Multidisciplinary collaborations to ensure modelling and simulation methods (e.g., QSP, MBDD, PBPK) inform internal decision making and external regulatory relations
• Foster cross functional (Clinical operations, Research, Bioanalysis, Biometrics, CMC and Clinical Sciences) collaborations to guarantee seamless implementation of Phase I-III studies
• Capable of integrating PK, PD, and safety data from multiple sources to optimize dosing for patient populations across the development continuum
• Offer input on preclinical-stage programs to augment preclinical effectiveness and biomarker data to support the progression of programs into clinical development
• Advocate for MIDD across drug discovery and development
• Actively identify state-of-the-art quantitative approaches in the field for potential applications to projects

Qualifications

• PharmD or PhD or MS in a field related to Pharmacometrics with at least 5-8 year(s) of industry or similar experience in Pharmacometrics, Clinical Pharmacology or Quantitative Systems Pharmacology
• Demonstrated exemplary PK/PD experience in managing clinical and nonclinical projects
• Current knowledge of regulatory guidances, global regulations, and SOPs in the conduct of clinical pharmacology studies
• Experience with authoring/reviewing clinical pharmacology documents for submission and/or response to regulatory agencies
• Experience in using modeling and simulation techniques in pharmaceutical development, such as population PK/PD modeling, PBPK modeling or QSP modeling
• Exceptional oral and written communication skills and excellent problem-solving skills
• Demonstrated past performance of functioning efficiently in a dynamic, cooperative, team-oriented environment showcasing emotional intelligence (respect and empathy)
• High proficiency in using one or more of the common software and data analysis packages (e.g., R, WinNonlin, Simcyp, GastroPlus, Monolix, NONMEM)

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

Design and management of safety pharmacology, exploratory and GLP toxicology studies. Handle multiple projects in a timely and effective manner at various stages of discovery, preclinical and clinical development.  Write, interact, and/or contribute to all applicable Regulatory Documents/Authorities and Asset Teams.

Responsibilities 

• Lead toxicology strategy and tactics in discovery, preclinical development and clinical development with a focus on understanding/assessing the human risk of novel therapeutic targets and/or understanding mode of action for toxicity in nonclinical studies
• Participate in multi-disciplinary team efforts and implement program-specific toxicology strategies to support compound and program progression
• Serve as the internal study directory and primary point-of-contact with CRO partners, interacting with technical, veterinary, and scientific staff
• Monitor outsourced GLP and non-GLP studies ensuring compliance with the protocol, amendments, regulations, safety guidelines, and standard operating procedures
• Write and review toxicology reports and documentation for regulatory filings, and participate in regulatory interactions
• Apply a broad understanding of toxicology, pharmacology, ADME, and knowledge of applicable regulatory guidelines to the design of appropriate toxicology studies and development plans
• Provide creative approaches to expedite nonclinical development strategies
• Provide a critical review of toxicology study protocols, data and study reports
• Serve as the Toxicology representative on multi-functional project teams supporting discovery and development phase projects
• Contribute to the preparation of high-quality regulatory documents supporting global clinical development and marketing authorizations
• Effectively communicate toxicology study results to project teams and senior level management
• Travel required as needed.

Required Qualifications 

• Ph.D. in Toxicology, Pharmacology, or a related field with a minimum of 5 years of industry experience as part of a drug development project team or a minimum of 5 years FDA experience reviewing nonclinical regulatory submissions
• Substantial nonclinical development experience at a pharmaceutical or biotechnology company or with the FDA
• Experience in designing, monitoring and interpreting nonclinical toxicology/safety pharmacology studies
• Experience in writing and reviewing nonclinical sections of regulatory documents (CTA, IND, IB, NDA, BLA, etc.) and direct interactions with worldwide regulatory agencies

Bonus Qualifications

• Certification by the American Board of Toxicology (DABT) is highly desired

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

Nurix is seeking a candidate for the role of Bioinformatics Scientist in the Proteomics group within Discovery Technologies and Early Research. This individual contributor role will focus on designing, implementing, and optimizing tools and workflows for proteomics data analysis, visualization, and interpretation. The candidate will creatively expand the capabilities of Nurix’s proteomics platform by integrating and developing customized tools for both global and targeted proteomics data analysis workflows. In this highly collaborative position, the candidate will work closely with proteomics team members, IT & informatics teams, biologists, and project leads, applying their tools and expertise to advance targeted protein degradation drug discovery. This candidate will also implement tools used throughout the degrader R&D life cycle to advance drug candidates alongside colleagues in Medicinal Chemistry, Biology, and Safety Assessment.

Required Skills & Experience:

Ph.D. in Biology, Chemistry, Biochemistry, Bioinformatics, or a related field with 0-3 years post-Ph.D. experience

• Expertise in:
  • Bioinformatics analysis of proteomic datasets with a focus on global proteomics workflows; familiarity with targeted proteomics is also valuable
  • Tools used for analyzing and visualizing differential expression datasets
  • Development and optimization of scripts in R and/or Python for proteomics data analysis
  • Standard statistical methods for large-scale data interpretation
• Strong experience in analyzing, condensing, and presenting complex datasets to diverse teams
• Knowledgeable in computational applications for global proteomic data
• Knowledgeable in post-translational modification (PTM) enrichment workflows

Preferred Skills & Experience

• Experience implementing or managing proteomics-related databases
• Direct experience with MS data processing tools & software
  (eg Skyline, Spectronaut/DIA-NN, MaxQuant, FragPipe)
• Knowledge of protein ubiquitylation biochemistry and pathways
• Familiarity with cloud computing platforms (e.g., AWS) for data storage and analysis
• Experience with machine learning (ML) or artificial intelligence (AI) for data analysis
• Knowledge of protein degradation pathways or prior experience in degrader drug discovery
• Strong publication record (e.g., peer-reviewed publications) and conference presentations.

Culture & Team Fit:

• Ability to work collaboratively across multiple groups within the organization
• Excellent organization and communication with effective presentation skills
• Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment
• Curious mindset with a willingness and flexibility to learn new skills
• High level of creativity and productivity with strong problem-solving skills

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Position:
Nurix Therapeutics, Inc. is seeking a Biosample Manager to join the Development Operations team. This is a full-time position, and the individual will report to the Senior Biosample Manager. This individual will work cross functionally, with both internal and external stakeholders, to plan, coordinate, and oversee all operational activities required to manage the lifecycle of the clinical biosamples.

Responsibilities:

•    Provide guidance during protocol and informed consent from development to ensure logistical feasibility of biosample handling, alignment with planned analyses and ICH/GCP compliance
•    Provides operational leadership in the form of guidance and support on vendor and sample management activities
•    Manage kit design, sample processing, collection, storage and shipping to ensure that the investigator sites can meet the sample handling needs of the study
•    Participate in the CRF development process to ensure that biosample information is appropriately captured for sample tracking and reconciliation purposes
•    Manage laboratory vendors including technology transfers, budgets, contract management, and data management
•    Plan, coordinate and oversee sample shipments and query resolution at laboratory vendors
•    Manage the sample management platform to track the life cycle of the samples, identify trends and gaps and obtain sample metrics
•    Provide adequate training and guidance to the investigator sites and study monitors for biosample collection, handling and shipment
•    Serve as an active member of the Clinical Study Teams and provide regular biosample metrics/trends and status updates
•    Develop and maintain biosample related SOPs and WPs

Experience and Skills:
•    B.S./ B.A. in biological sciences with 5+ years of relevant industry experience
•    Knowledge of FDA & ICH/GCP regulations and guidelines
•    Proficiency in MS office including Word, Excel, PowerPoint and other applications
•    Proven track record of sample management, data management and contract management skills
•    Ability to manage work flows and data sets
•    Good initiative and ability to work independently
•    Ability to work in a fast-paced environment
•    Excellent written and interpersonal communication skills
•    Detail oriented with the ability to manage multiple competing priorities
•    Effective team player and ability to collaborate with cross functional clinical study teams

To Apply: Please provide a cover letter and resume

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

Nurix is seeking a highly qualified Cheminformatics Scientist to join the Early Drug Discovery team, specifically within the Cheminformatics and Machine Learning department. This individual contributor role will play a crucial part in advancing our drug discovery efforts by designing, implementing, and optimizing cheminformatics tools and workflows. While the primary emphasis of this role will be supporting our DNA Encoded Library (DEL) and DEL-AI platforms, the successful candidate will additionally advance broader cheminformatics support for our degrader discovery and development teams.  The successful candidate will collaborate extensively with teams in DEL, machine learning, IT & informatics, medicinal chemistry, and early discovery, contributing to all stages of the drug discovery pipeline, from library design and data analysis to hit identification and lead optimization.  

Responsibilities 

• Support project teams by providing cheminformatics expertise and contributing to data interpretation and decision-making.
• Develop and implement tools and workflows for enabling application of our DEL platform, including library enumeration, data query, extraction, interpretation, and hit follow-up.
• Collaborate with the DEL production team to design libraries, including chemical space analysis, building block and codon selection, library onboarding, and quality control.
• Design, create, and test new cheminformatics tools and visualizations to support DEL and machine learning data analysis, as well as general drug discovery data needs.
• Maintain and enhance existing cheminformatics codebases, ensuring their reliability and performance.
• Develop and deploy advanced queries to integrate data and enable interpretation from diverse Nurix databases 

Required Skills & Experience: 

• Ph.D. in Chemistry, Cheminformatics, or a related field with 0-3 years post-Ph.D. experience
• Demonstrated expertise in cheminformatics principles and techniques, including reaction SMARTS, chemical fingerprints, similarity comparison, and clustering.
• Direct experience with informatics and cheminformatics solutions for DNA Encoded Libraries
• Proficiency in data processing, analysis, and visualization software (e.g., KNIME, Spotfire)
• Experience with database query languages (e.g., PostgreSQL, Oracle, AWS).
• Strong programming skills in Python for data analysis, visualization, and tool development, including experience with relevant libraries such as Pandas, Matplotlib, and RDKit. 

Preferred Skills & Experience 

• Excellent organization and communication with effective presentation skills
• Have experience building and designing databases
• Basic understanding of chemistry and medicinal chemistry concepts 

 Culture & Team Fit: 

• Ability to work collaboratively across multiple groups within the organization
• Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment
• Curious mindset with a willingness and flexibility to learn new skills
• High level of creativity and productivity with strong problem-solving skills 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

Nurix, Inc. is seeking a Clinical Program Manager (CPM) to join the Clinical Operations team.  This individual will be responsible for management of global clinical programs. They will lead study team, vendors, clinical monitors and clinical sites throughout the life cycle of a clinical program.

This individual will be able to manage multiple study teams across a program and have broad involvement in work central to Nurix’s strategic goals. They will apply existing technical skills, learn new skills, and play a key role in nonclinical development of the programs and help grow the company and guide its direction. As an early hire, They’ll be influential in championing and developing Nurix’s culture.

CPM is responsible for the successful implementation of a clinical program, including providing mentorship and oversight of all aspects of international clinical trials within designated program budgets and timelines. Experience in leading staff as well as mentoring and developing junior staff will be essential to the team's success. The CPM will represent Clinical Operations at Project team meetings and may represent company at professional events.

Responsibilities:

• Accountable for all operational aspects of clinical trials within the assigned program
• Provides guidance and oversight for the successful management of all aspects of international clinical trials within designated program budgets and timelines.
• Examine functional issues from a broader organizational perspective and develop a strategy to implement with a cross-functional team
• Provides program level oversight to vendors, including CRO, central lab, and imaging.
• Proactively identifies potential issues/risks across the program and recommends/implements solutions.
• Participates in the selection, training and evaluation of clinical trial managers and clinical trial management associates to ensure the efficient operation of the function.
• Attends and presents at cross-functional meetings as needed to represent Clinical Operations and program level items
• Provides mentorship and career development to direct reports.
• Provides leadership to the clinical operations team working on the assigned program.

Experience and Skills:

• B.S./ B.A. in biological sciences, advanced degree preferred with 10+ years of relevant industry experience, including oncology experience
• Ability to travel as required for the program (10-15%)
• Demonstrated knowledge of FDA, ICH and GCP regulations and guidelines
• Experience in leading teams, including CROs, consultants and vendors.
• Proficient in developing trial plans and implementing operational changes across multiple studies
• Highly developed leadership skills to successfully lead multiple direct reports
• Must display strong analytical and problem-solving skills at a program level and collaborate with colleagues to generate solutions
• Strong communication and influence skills and ability to create a clear sense of direction
• Ability to deal with time demands, incomplete information or unexpected events
• Outstanding organizational skills with the ability to multi-task and prioritize
• Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Nurix, Inc. is seeking a Clinical Trial Manager (CTM)/Sr. CTM to join the Clinical Operations team.  This individual will be responsible for management of assigned clinical trials and/or global regions. They will lead study team, vendors, clinical monitors and clinical sites throughout the life cycle of a clinical trial.

This individual will be able to manage clinical regions and/or trial(s) and have broad involvement in work central to Nurix’s strategic goals. They will apply existing technical skills, learn new skills, and play a key role in clinical development of the programs.

The CTM/Sr. CTM is responsible for the successful implementation of assigned clinical trial(s), independently, from start-up to close-out. Experience in managing cross-functional teams, vendor oversight, knowledge of applicable regulatory requirements and developing junior staff will be essential to the team's success. The CTM/Sr. CTM will represent Clinical Operations at Project team meetings and may represent Nurix at professional events.

Job Responsibilities:

• Accountable for all operational aspects of assigned clinical trial(s) and/or geographical region.
• Develop and implement clinical trial protocols, including study objectives, inclusion/exclusion criteria, and data collection procedures
• Responsible for selection of vendors/CROs and provide effective ongoing management and oversight to vendors/CROs to ensure compliance and execution of deliverables within the approved budget, study timeline, and study protocol
• Works closely with investigative site personnel, CROs, and other study vendors
• Manage relationships with site investigators and study coordinators
• Monitor and track clinical trial progress and provide status update to stakeholders
• Monitor recruitment progress and effectively address enrollment challenges
• Manage study contracting, budget, forecasting, accruals and payment process for all clinical trial vendors including investigational sites
• Collaborate with Data Management to ensure correct CRFs content is collected, prepare/implement CRF completion guidelines, and coordinate delivery of data updates, listings and study reports
• Drafts and coordinates review of relevant documents including protocols, informed consents, case report forms, monitoring plans and relevant study plans, investigator brochures and clinical study reports.
• Prepare for and manage regulatory agency audits and inspections
• Must be able to participate in cross-functional strategic initiatives under limited supervision
• Proactively identifies potential issues/risks and recommends/implements solutions
• Provides leadership to the clinical operations team working on the assigned clinical trials

Experience and Skills

• B.S./ B.A. in biological sciences with 5+ years of relevant industry experience
• Ability to travel as required for the program (25%)
• Demonstrate knowledge of FDA, EMA, ICH and GCP regulations and guidelines
• Experience managing global trials
• Experience in leading teams, including CROs, consultants and vendors
• Must display strong analytical and problem-solving skills at a project level and collaborate with colleagues to generate solutions
• Strong communication and influence skills and ability to create a clear sense of direction
• Ability to deal with time demands, incomplete information or unexpected events
• Outstanding organizational skills with the ability to work independently, multi-task and prioritize
• Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

Nurix is seeking a highly skilled and motivated Cloud Compute and Database Developer to join our dynamic Early Drug Discovery team, specifically within the Cheminformatics and Machine Learning department. This critical role will empower Nurix scientists to leverage our extensive DNA Encoded Library (DEL) and Degrader datasets, driving innovation in drug discovery. As a key member of the team, you will collaborate closely with a diverse group of scientists, informaticians, and engineers, contributing to the development and maintenance of cutting-edge infrastructure solutions. This includes designing, building, and optimizing high-performance computing (HPC) environments, scalable cloud-based data processing pipelines, and robust database systems.  This position offers a unique opportunity to work at the intersection of biotechnology, machine learning, and high-performance computing, directly impacting the future of medicine. 

  Responsibilities 

• Collaborate with research teams to design and implement data processing solutions and workflows tailored to bioinformatics needs.
• Manage high-performance computing (HPC) infrastructure, ensuring efficient automation and scalability.
• Develop interactive dashboard-style front ends for user interaction with backend systems.
• Design, build, and optimize database systems, complex queries, ETL pipelines, and reporting frameworks across informatics silos, ranging into terabyte scale.
• Maintain and improve existing web applications and backend systems in production to ensure reliability and performance.
• Provide mentorship and support to team members, fostering growth in problem-solving skills, development techniques, and best practices. 

 Required Skills 

• Programming Languages: Python, JavaScript.
• AWS Services: Hands-on experience with AWS, especially EC2, S3, Batch, Athena, SageMaker, RDS, and EMR.
• Database Expertise: Advanced knowledge of SQL for complex queries and data management.
• DevOps: Docker, Linux, Anaconda, CI/CD pipelines.
• Python Libraries: pandas, boto3, awswrangler, matplotlib, streamlit, pyshiny, flask, fastapi. 

Additional Useful Skills 

• C/C++ and R
• Tibco Spotfire
• Windows
• Machine learning (ML) workflows and MLOps
• Apache Spark, Hive
• Experience working in a biotech and basic understanding of science 

 Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

The Director of Corporate Communications will develop and execute the company’s corporate communications strategy, with a strong focus on external communications, investor relations, and internal communications. This position will be responsible for developing and delivering key messages across various channels, supporting the creation of content for investor relations and corporate presentations, and ensuring alignment between the communications teams in Research, Clinical Development, and Investor Relations.

The Director will play a pivotal role in maintaining the company’s public image, ensuring the company’s website is current, and proactively managing corporate messaging across internal and external stakeholders. This is an exciting opportunity to contribute to a growing pharmaceutical company, with potential for career development within the corporate communications function.

Key Responsibilities:

• Corporate Communications Strategy: Develop and implement a comprehensive corporate communications strategy that aligns with the company’s vision, values, and business goals. Manage both internal and external communications, ensuring consistency and clarity across all channels.
• Investor Relations Communications: Support the investor relations function by creating and updating content for investor decks, press releases, and other investor-facing communications. Ensure that key messages are communicated effectively to shareholders, analysts, and other stakeholders.
• Website Management and Content Development: Oversee the company’s website, ensuring it is up to date with the latest company developments, research updates, clinical trials, investor relations content, and other corporate information. Collaborate with cross-functional teams to create fresh, engaging content that represents the company’s innovations and achievements.
• Content Creation: Write and produce high-quality content for various corporate materials, including press releases, blog posts, newsletters, annual reports, and executive communications. Ensure messaging aligns with the company’s corporate narrative and business objectives.
• Cross-functional Collaboration: Serve as a liaison between the Corporate Communications, Research, Clinical Development, and Investor Relations teams. Coordinate the creation of a unified communication calendar to align efforts, key dates, and messages across departments.
• Internal Communications: Develop and implement effective internal communications strategies to keep employees informed and engaged with company developments, milestones, and leadership updates. Foster a positive internal culture through transparent and consistent communication.
• Crisis Communication and Reputation Management: Support the development of crisis communication plans and manage media inquiries in the event of any negative publicity. Monitor and manage the company’s reputation in both traditional and social media.
• Media Relations: Cultivate relationships with key media outlets, journalists, and industry influencers to secure media coverage and promote the company’s achievements. Respond to media inquiries and ensure timely and accurate responses.
• Leadership Support: Work closely with the Chief Business Officer and other executives to develop executive speeches, presentations, and other communications materials to effectively represent the company in meetings, conferences, and public engagements.
  
  

Qualifications:

• Bachelor's degree in Communications, Public Relations, Marketing, or relevant scientific field. Advanced degree or professional certification in communications or investor relations preferred.
• Minimum of 10+ years of work experience in corporate communications within the pharmaceutical, biotechnology, or healthcare industries.
• Strong knowledge of pharmaceutical industry trends, clinical development processes, and investor relations practices.
• Proven ability to develop and implement strategic communication plans, including writing, editing, and creating content for a variety of formats.
• Experience in managing corporate websites and digital content, with a focus on maintaining up-to-date, engaging content.
• Familiarity with regulatory and compliance guidelines related to corporate and investor communications in the pharmaceutical industry.
• Excellent written and verbal communication skills, with a talent for crafting clear, concise, and persuasive messages.
• Strong project management and organizational skills, with the ability to manage multiple priorities and deadlines.
• Ability to collaborate effectively across functions and manage complex stakeholder relationships.
• Experience working with executives and preparing presentations and materials for external and internal audiences.
• High degree of professionalism and confidentiality, with an ability to handle sensitive information responsibly.
• Ability to think strategically and proactively manage communications needs across the organization.
• Travel requirement - 40% 

What We Offer:

• Competitive salary and benefits package.
• Opportunities for career growth and development within corporate communications.
• A dynamic, fast-paced work environment with the chance to influence the company’s public and internal communications.
• Supportive leadership and a collaborative team culture.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

This job description includes a comprehensive set of responsibilities and qualifications while also emphasizing opportunities for growth in corporate communications within the company. The role's focus spans external, internal, and investor communications, all within the context of a growing pharmaceutical organization.

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

• The  Executive Director Global Value and Market Access will be responsible for developing and executing differentiated global market access and pricing strategies demonstrating the value of our assets to HTA bodies and payers to ensure optimal patient access. The ideal candidate will have a solid analytical background, strategic thinking as well as a deep understanding of US / EU /Japan/ Canada regional healthcare systems, payer preferences, and market dynamics to lead the market access and pricing launch strategies.

Responsibilities

• Lead the development of Global Integrated Access and Pricing strategies in collaboration with the cross-functional team to maximize the value of assigned asset(s),
• Provide strategic market access input to inform global clinical development program of assigned asset(s) and ensure it is optimized to meet the needs of global payers (e.g., relevant endpoints, trial design, sub-populations, evidence of cost offsets) by incorporating HTA and payers’ perspectives gained through early HTA engagement, ad boards, primary payer research, and analysis of select secondary research,
• Develop and maintain strong business relationships with key functions responsible for value proposition enablement with a focus on clinical, commercial, regulatory, medical affairs, and HEOR stakeholders,
• Proactively identify and communicate evidence requirements for successful access and support the development of evidence generation plans in collaboration with HEOR,
• Collaborate with Market Access colleagues (Global and in countries) to drive alignment, optimize support, and promote efficiency and best practice sharing,
• Monitor, analyze and communicate Global market access and pricing trends, competitor activities, and policy changes to anticipate future market dynamics and adjust strategies accordingly,
• Support the execution of broader market access goals, including pricing targets, access timelines, and overall launch success,
• Plan and contribute to JCA submission.

Requirements

•  Ph. D, Pham D, M. Sc. in appropriate field (Health Economics, Public Health, or Health Policy) preferred.
• +10 years of relevant experience working within a similar organization including international exposure within a leadership position,
• Strong experience in pricing and reimbursement of hematology / oncology products with specific knowledge of and demonstrated experience in one of the key HTA markets (i.e., UK, Germany, France, Canada),
• Strong experience with pricing regulations and a hands-on role in early and launch Pricing analysis. Hands-on experience with country pricing negotiations is a plus,
• Demonstrable experience supporting the early global development plans to meet the evidence requirements for the various downstream market access stakeholders,
• Proven track record of success within developing desirable value propositions and access strategies,
• Demonstrated knowledge of global policy trends, tactics, and HTA/payer dynamics incl. regional developments (e.g., JCA, IRA),
• Experience in making market access recommendations on products in development and suggesting changes for optimization of market access,
• Demonstrated success in managing multiple activities (both "self" and through delegation) and working in a fast-paced environment,
• Proven track record of providing thought leadership, influencing decisions across all levels of the organization, and driving results through teams,
• Fluency in English and an additional language would be a strong advantage.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

Nurix is seeking a talented, inquisitive, and passionate Machine Learning Scientist to join our cutting-edge research team and revolutionize the development of Targeted Protein Degradation (TPD) therapeutics. The successful candidate will play a pivotal role in building and applying our robust ML Platform to accelerate drug discovery. This involves collaborating closely with interdisciplinary project teams, identifying critical research challenges amenable to machine learning solutions, developing high-quality predictive models, and deploying these models to streamline the drug design process. You will leverage our extensive DNA Encoded Library (DEL) and Degrader datasets to drive impactful decisions at every stage of the drug development pipeline 

Responsibilities 

• Develop and deploy high-performing machine learning models to address critical research needs within the TPD drug discovery pipeline.
• Apply Nurix's DEL ML and DEL Foundation platforms to guide Lead Identification and Lead Optimization efforts, extracting valuable insights from our experimental DEL platform.
• Design and conduct rigorous model validation and performance assessments to ensure the reliability and robustness of ML predictions.
• Collaborate effectively with cross-functional research teams (e.g., chemists, biologists, engineers) to translate research questions into actionable ML problems.
• Advocate for the adoption of machine learning solutions within the research organization, effectively communicating the value and impact of ML-driven insights.
• Maintain and enhance existing machine learning codebases, ensuring their scalability, maintainability, and performance.
• Stay abreast of the latest advancements in machine learning research and technologies, identifying opportunities to incorporate novel methods into our drug discovery efforts 

. Desired Qualifications 

• Recent PhD or strong experience (MS + 1-3 years or BS + 3-5 years) in Machine Learning, Bioinformatics, Computational Biology, Computer Science, Statistics, or a related field.
• Demonstrated Python proficiency and experience with modern frameworks for Machine Learning: Proven experience implementing projects with supervised and unsupervised learning algorithms using modern python packages (e.g., linear regression, logistic regression, support vector machines, random forests, clustering, deep learning, scikit-learn, PyTorch, Tensorflow).
• Data analysis and visualization: Experience with data cleaning, preprocessing, exploratory data analysis, and visualizing results (e.g., pandas, NumPy, matplotlib, seaborn)
• Familiarity with one or more cheminformatic or computational toolkits (RDKit, OpenBabel, OpenEye, Schrodinger, etc)
• Experience working in Linux/Unix environments including basic shell scripting and bash commands.
• Experience with cloud platforms (e.g., AWS, Azure), version control systems (e.g., Git), CI/CD pipelines and workload managers (e.g., Slurm)
• Experience designing experiments with scientific data: Prior research involving chemical, biological, or DNA Encoded Library datasets      
• Strong communication and interpersonal skills 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Job Summary:

Nurix Therapeutics, Inc. is seeking a Manager/Sr. Manager/Associate Director, Regulatory Affairs (Strategy, Hematology Oncology) to join the Regulatory team.  The successful candidate will be a core member of the Regulatory team and will be responsible for helping build and execute on global regulatory strategy, objectives, policies and programs pertaining to development and future marketing of products, for guiding and executing upon regulatory strategy of compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities. This includes supporting regulatory activities to enable clinical development plans and studies, working cross-functionally across the organization.

Responsibilities:

• Provides regulatory strategic direction and support for assigned global development programs/development program activities
• Assists Sr. Regulatory Affairs staff with their development program activities and deliverables
• Designs and implements regulatory strategies with Regulatory Affairs staff to obtain and maintain product investigative and marketing applications for assigned programs, as well as their life cycle management
• Acts as regulatory representative on early and/or late phase clinical studies, ensuring compliant execution of trials
• Strong competency in understanding regulatory requirements and emerging regulatory landscapes associated with US and global regulatory authorities
• Experienced in responding to inquiries from global regulatory authorities as well as the preparation and conduct of meetings with global regulatory authorities
• Assist in the preparation and maintenance of Annual Reports, Development Safety Update Reports (DSURs), Investigator’s Brochures and other documents required for INDs, CTAs, NDAs and other related regulatory development and marketing applications
• Assist in the cataloging and maintenance of regulatory application submissions
• Conduct research and stay up-to-date on regulatory requirements and changes
• Collaborate with cross-functional teams to ensure product compliance throughout the development lifecycle
• Monitor and assess regulatory risks and develop mitigation strategies
• Oversee quality assurance processes to ensure compliance with regulatory standards
• Review SOPs pertaining to Regulatory
• Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
• Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
• Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
• Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
• Participates in cross-functional process initiatives impacting regulatory submission processes and systems
• Manages consultants and contractors as needed

Experience and Skills:

• Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred Manager:
• Must have minimum of 8 years in Regulatory affairs strategy
• Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
• Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
• Ability to read, analyze and interpret scientific and technical information, as well as regulatory
• Ability to understand and explain detailed regulatory affairs and compliance programs and/or to effectively present information to senior regulatory management, other departments or external
• Ability to comply with changing regulatory
• Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
• Strong project management and critical thinking skills
• Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
• Excellent organizational and communication skills, both written and verbal
• Ability to work independently as well as part of a team environment
• Positive attitude, energetic and proactive
• Proven ability to manage multiple projects, identify and resolve regulatory issues
• Strong interpersonal skills and the ability to effectively work with others

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Position

The successful candidate will be responsible for the execution of translational activities toward Nurix’s clinical development programs targeting protein fate for cancer targeted therapy and immunotherapy. Collaborating with the multiple organizations at Nurix, the translational Sci I/II will be responsible for executing preclinical studies, analysis, and interpretation of data to guide indication selection for early clinical development. 

Specific responsibilities include: 

• Utilize broad technical expertise in cell and tumor immunology, biochemistry, and molecular biology to investigate, develop and optimize new methods to expand mechanistic understanding of Nurix’s clinical development assets.
• Build and maintain a knowledge of current and emerging biomarker assay technologies in area of expertise.
• Incorporate state of the art technological advances into biomarker and clinical strategies to guide indication selection, and combination strategies for global development
• Oversight of technical transfer of clinical biomarker assays to partner labs
• Responsible for the biomarker strategy for clinical studies; working closely with the clinical team and non-clinical stakeholders
• Support scientific input and review of all translational medicine aspects of clinical and regulatory documents, including but not limited to development plans, study protocols, clinical study reports and regulatory submissions.
• Communicate translational research efforts to collaborators, corporate partners, and/or at scientific meetings

Education and Skills Requirements:

• MS degree with 6+ years or Ph.D. degree with 2+ industry experience in cell biology, immunology, pharmacology, translational medicine, or related discipline. Level commensurate with experience.
• Strong background in human B cell biology. Knowledge in T cell biology is an advantage. Ideally, candidate will have training and/or experience in designing and implementing in vitro functional cell culture assays, including assessments of cytotoxicity, cytokine production and proliferative capacity.
• Demonstratable experience in multi-color flow cytometry panel design and characterization of cellular subsets in human blood and tissue is required.
• Ability to troubleshoot and interpret complex data in an independent fashion
• Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage
• Excellent interpersonal, verbal, and written communication skills, creative thinking, problem solving, flexibility and demonstrated ability to harness existing data sets to inform translational research are essential for this role.
• Collaborative spirit and ability to work with project teams, external investigators, and contract research organizations.
• Highly motivated, innovative, and strong team player. Excellent time management and organizational skills required.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The candidate will be responsible for chemical development-related activities across the portfolio including process development and manufacture of regulatory starting materials (RSMs) and supporting production of Drug Substance (DS) for clinical trial materials, and establishment of associated control strategy for RSMs and DS to support CMC regulatory documents. The ideal candidate will be a highly motivated chemist with experience and interest in working in a small, entrepreneurial environment with broad responsibilities and opportunities.

Principal Duties and Responsibilities

• Development of robust, scalable, and cost-effective phase-appropriate manufacturing process that meet or exceed quality and regulatory requirements
• Work up to 50% of the time in the lab to support process route development and ongoing production campaigns
• Responsible for supporting RSMs and DS manufacturing related activities, including scale-up of compounds to support internal and external drug development
• Author tech transfer documents and work with CROs/CDMOs to effectively and efficiently reproduce chemistry at various sites
• Support phase-appropriate process characterization, identify critical quality attributes, and implement controls, including selection and justification of RSMs to ensure that all CROs and CMOs are using systems and processes in compliance with all relevant regulatory standards and to ensure consistency of DS quality
• Prepare, review, or edit technical reports, protocols, cGMP batch records, CMC regulatory submissions and Quality documents
• Collaborate with cross-functional teams, including analytical chemistry, formulation, quality and regulatory to support drug development programs
• Travel up to 25%

Skills and Background

• PhD with 2+ years of experience or MS with 5+ years of experience; advanced degree in Organic Chemistry, Chemical Engineering, Pharmaceutical Chemistry, Pharmaceutics, Pharmaceutical Science, or related scientific discipline,
• 1-3 years relevant experience in a pharmaceutical or biotechnology CMC/cGMP environment preferred
• Hands-on experience in multi-steps organic synthesis. Familiarity with common analytical techniques (e.g., HPLC, NMR, mass spectrometry)
• Strong working knowledge of synthetic organic chemistry and the ability to leverage it toward route development and rapid synthetic triage
• Experience leveraging US and International CRO/CMOs for the manufacture of RSMs and DS to meet aggressive timelines
• Excellent problem-solving skills and the ability to identify, resolve critical issues, and work independently
• Experience implementing technical, strategic, and operational plans
• Excellent written and verbal communication skills, exceptional interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators)
• Strongly team oriented

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age or genetics. In addition to federal law requirements, Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Nurix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, or veteran status. Improper interference with the ability of Nurix’s employees to perform their job duties may result in discipline up to and including discharge.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Position: Nurix is seeking a highly motivated and experienced Senior Scientist to join our Chemical Development team. The successful candidate will play a critical role in the development and optimization of chemical processes for the synthesis of novel therapeutic compounds. This position requires a deep understanding of organic chemistry, process development, and scale-up, as well as strong problem-solving skills and the ability to work collaboratively in a fast-paced environment.

Key Responsibilities:

• Characterize impurity profile of the manufacturing process and conduct impurity fate and purge experiments
• Design and conduct process characterization studies (OVAT and/or DOE) for the manufacturing process
• Mentor and provide guidance to junior scientists and research associates.
• Design and develop robust and scalable chemical processes for the synthesis of small molecule therapeutics.
• Optimize reaction conditions and improve process efficiencies to ensure high yield and purity.
• Collaborate with cross-functional teams, including analytical chemistry, formulation, quality and regulatory to support drug development programs.
• Troubleshoot and resolve complex synthetic and process-related challenges.
• Author tech transfer documents and work with CROs/CDMOs to effectively and efficiently reproduce chemistry at various sites.
• Prepare and review technical reports, protocols, and assist in the preparation of regulatory documentation, INDs, CTAs, NDAs and MAAs.
• Present findings and updates to internal and external stakeholders.
• Work up to 60% of the time in the laboratory.

Qualifications:

• Ph.D. in Organic Chemistry, Chemical Engineering, or a related field with 3+ years of relevant industry experience, or M.S. with 5+ years of experience.
• Proven track record in chemical process development and scale-up.
• Demonstrated experience with NDA supportive characterization studies (OVAT and/or DOE) and identification of critical process parameters (CPPs) for process validation
• Strong knowledge of modern synthetic organic chemistry techniques and methodologies.
• Familiarity with analytical techniques such as HPLC, NMR, and mass spectrometry.
• Experience with process optimization, including reaction kinetics, thermodynamics, and mechanistic studies.
• Familiarity with regulatory requirements and guidelines for pharmaceutical development.
• Excellent problem-solving skills and the ability to work independently and as part of a team.
• Strong written and verbal communication skills.
• Ability to manage multiple projects and prioritize tasks effectively.

Bonus Qualifications:

• Experience in the pharmaceutical industry, particularly in late stage process development.
• Hands-on experience of scaling up processes in 5-20 L jacketed reaction vessels.
• Experience in setting up and maintaining 1-20 L jacketed reaction vessels and auxiliary systems.
• Experience in the use of Dynochem for process modeling.
• Experience in the use of Design of Experiment software such as JMP and/or Design Expert

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age or genetics. In addition to federal law requirements, Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Nurix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, or veteran status. Improper interference with the ability of Nurix’s employees to perform their job duties may result in discipline up to and including discharge.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Director, Clinical Science 
  
As an integral member of the Clinical Development Team, this person will work closely in collaboration with the study teams providing scientific guidance and support. 
 
The Senior/Executive Director, Clinical Science will report to the VP, Head of Clinical Science and will be responsible for developing and contributing to the strategy to advance molecules through the Nurix clinical pipeline. This role will work cross-functionally and participate in the execution of clinical studies including protocols, provide scientific expertise to support site and CRA training, data cleaning/analysis, investigator interaction and support of regulatory filings. In collaboration with the Medical Monitor and Safety team this role will be responsible for safety oversight of clinical trials. 
 
Job Responsibilities: 

• Participate, contribute and/or lead cross-functional clinical development teams with strong ability to work closely with all team members, address study or other program-specific questions. 

• Develop the Global Development plan with senior clinical development staff 

• Implement Global Development Plan with strategic clinical science support  

• Lead in reviewing and authoring clinical protocols.  Read and interpret scientific and medical literature for the use in clinical documents and to assist clinical team decision making. 

• Prepare clinical portions of all relevant regulatory filings and meeting packages (INDs, Annual Reports, meeting requests, NDAs, etc.) for US and ex-US Health Authorities.  

• Integrate scientific knowledge and operational expertise to ensure translation of clinical research plans into efficiently delivered high quality studies. 

• Acquire and utilize knowledge of clinical trial design and relevant disease indications to assist in study concept and protocol development. Contribute to discussions concerning scientific and procedural aspects of study design. Coordinate with departments to produce the final protocol and informed consent documents. 

• Contribute and review medical data review plans, Data Safety Monitoring Board (DSMB)/Safety Review Committee (SRC) charters, and specific sections of study manuals and investigator meeting materials. 

• Contribute to the development of CRFs, data edit checks, patient profile design, ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis. 

• Lead internal clinical data review meetings in conjunction with the medical monitor; lead the data preparation effort for dose escalation meeting, as applicable to study stage. 

• Coordinate and manage external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, in conjunction with the medical monitor. 

• Research and summarize published literature for continual learning and to prepare training materials for other clinical team members. 

• Contribute to statistical analysis plans, table, listing, figure design and the preparation of manuscripts and other presentations of study data, as appropriate. 

• Address investigator questions regarding protocol and related scientific issues and attend site initiation visits (SIVs), in coordination with the medical monitor. 

• Assist in determining the activities to support a project's priorities within functional area 

• Train other clinical scientists as needed. 

• Medical monitoring duties may be considered depending on degree (e.g., PharmD, MD or other clinical advanced degree) and previous experience. 

• Support business development activities as needed serving as scientific/subject matter expert 

• Up to 25% travel (US and International) 

Basic Qualifications 
 
Advanced degree in clinical or biological sciences (MD, PhD, or PharmD preferred) and 12+ year's (Senior Director) or 15+ years (Executive Director) relevant drug development experience with minimum of 5 years’ experience in oncology clinical trials. 
 
Preferred Qualifications 

• Experience in the clinical science role, in an oncology indication for first-in-human and proof of concept studies in small molecules, biologics and/or cell therapy. Registrational or Phase 3 study experience is desired.  

• In depth understanding of clinical operations and translational medicine. 

• Excellent interpersonal and communication skills. 

• Able to translate technical concepts into accessible language and direction for the broader study team. 

• Excellent attention to detail, collaboration and initiative, with flexibility to adapt to the needs of the organization; maintain meticulous attention to project deadlines. 

• Experienced in Microsoft Office (Excel, Word, PowerPoint, OneNote), and ideally also with job related programs such as Spotfire and Medidata Rave or similar. 

• Strong understanding of ICH GCP, as well as general knowledge of industry practices and standards 

• Commitment to patient safety and clinical compliance. 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

The Senior Executive Assistant will provide high-level administrative support to the Chief Scientific Officer (CSO) of a growing mid-sized pharmaceutical company. This position requires a highly organized, detail-oriented, and proactive individual who can handle complex scheduling, manage multiple priorities, and communicate effectively across various levels of the organization. The ideal candidate will have exceptional problem-solving abilities, strong written and verbal communication skills, and experience in managing the daily operations of a senior executive’s office. This position plays a crucial role in ensuring the smooth and efficient functioning of the CSO’s office and supporting strategic initiatives within the organization.

Key Responsibilities:

• Calendaring and Scheduling: Efficiently manage and prioritize the CSO’s calendar, scheduling meetings, travel, and appointments, while ensuring no conflicts. Proactively anticipate scheduling needs and adjust as required.
• Communication: Serve as the primary point of contact between the CSO and both internal and external stakeholders. Prepare, review, and edit communications including emails, memos, reports, and presentations, ensuring clarity and professionalism.
• Travel Coordination: Coordinate complex domestic and international travel arrangements, including flights, accommodations, ground transportation, and itineraries.
• Meeting Coordination and Event Planning: Plan and organize meetings, events, conferences, or seminars, including preparing agendas, coordinating logistics, and gathering materials.
• Project Support: Assist the CSO in the tracking of key projects and initiatives, providing status updates, tracking action items, setting reminders, and providing logistical support to facilitate progress.
• Presentation Support and Document Management: Assist with preparation of PowerPoint presentations. Maintain and organize files and documents, ensuring quick retrieval and confidentiality. Handle sensitive information with discretion.
• Ad Hoc Support: Provide additional administrative support as needed, including drafting correspondence, assisting with purchase orders, contract requests and expense reports, and handling special projects.

Qualifications:

• Minimum of Associates Degree required. Bachelor’s Degree preferred.
• At least 5+ years of experience in an executive administrative role, preferably in the pharmaceutical, healthcare, or scientific industry.
• Proven experience in managing complex calendars and schedules for senior executives.
• Strong organizational and multitasking skills, with a keen ability to prioritize tasks and meet deadlines.
• Exceptional written and verbal communication skills, with the ability to liaise professionally with all levels of the organization.
• Advanced proficiency in Microsoft Office Suite (Word, Excel, PowerPoint, Outlook).
• Ability to proofread documents, including letters, reports, presentations, and emails, ensuring accuracy in grammar, punctuation, formatting, and overall clarity.
• Ability to work independently and as part of a team, demonstrating initiative and problem-solving skills.
• Strong attention to detail and the ability to maintain confidentiality and exercise discretion.
• Flexible and adaptable to changing priorities in a fast-paced environment.
• A proactive approach to anticipating the needs of the CSO and offering solutions in advance.

Additional Skills (Preferred):

• Experience supporting executives in the pharmaceutical or biotech industries is a plus.
• Experience with project management tools (e.g., Asana, Trello) to aid with project management.
• Experience proofreading scientific documents and/or illustrations.
• Ability to coordinate virtual and in-person meetings seamlessly.

What We Offer:

• Competitive salary and benefits package.
• Opportunities for career growth within a dynamic, fast-paced company.
• A collaborative and supportive work environment.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

Nurix is seeking a highly accomplished and visionary Senior Machine Learning Scientist to lead the development and advancement of our cutting-edge ML platform. This critical role will be instrumental in driving innovation in drug discovery by leveraging the power of machine learning techniques to accelerate our targeted protein degradation (TPD) research programs. The successful candidate will provide strategic guidance for the application of our existing machine learning platform while spearheading research and integration of advanced methods such as foundational models and LLMs. You will possess a strong track record of research and development in machine learning, with a deep understanding of both fundamental concepts and their practical applications within the life sciences. 

Responsibilities 

• Lead the development and implementation of a state-of-the-art machine learning platform to support all stages of the TPD drug discovery pipeline.
• Research and develop novel machine learning methodologies, including foundation models, LLMs, and other cutting-edge techniques, and guide their application to Nurix degrader discovery programs.
• Guide the design and implementation of advanced AI/ML algorithms for tasks such as molecular design, property prediction, target identification, and lead optimization.
• Collaborate closely with research teams to identify and translate critical scientific challenges into tractable machine learning problems.
• Mentor junior scientists and foster a culture of innovation and excellence within the machine learning team.
• Stay at the forefront of cutting-edge research in machine learning, attending conferences, reviewing publications, and actively participating in the scientific community. 

 Desired Qualifications 

• Ph.D. in Machine Learning, Computer Science, Bioinformatics, Computational Biology/Chemistry, Statistics, or a related scientific field with appropriate experience.
• Extensive experience (5+ years) in machine learning research and development within the biotech or pharmaceutical industries, with a proven track record of successful project delivery.
• Strong foundation in core machine learning and deep learning algorithms, including supervised, unsupervised, reinforcement learning, and their application in drug discovery or life sciences contexts.
• Proficiency in Python and experience with deep learning frameworks (e.g., TensorFlow, PyTorch).
• Track record of leading and collaborating on machine learning projects from conception to adoption including model architecture, training, fine-tuning, and deployment. Preferred experience in GANs, VAEs, foundation models, reinforcement learning, LLMs, and their applications.
• Experience with scientific data, including chemical, biological, and/or genomic data.
• Experience with cloud computing platforms (e.g., AWS, Azure, GCP) and high-performance computing.
• Experience with MLOps practices (e.g., CI/CD, model monitoring, explainability).
• Excellent communication, presentation, and interpersonal skills with the ability to effectively communicate complex technical concepts to both technical and non-technical audiences.
• Strong leadership and mentorship skills with the ability to guide and motivate junior team members. 

• A strong publication record in top-tier machine learning conferences or peer-reviewed journals. 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Purpose:

 The Senior Manager Quality Assurance Operations will support the quality operations and support compliance activities of in its product development and commercialization efforts. This person will work closely with the company's CMC group assuring accurate and timely flow of information including, but not limited to: specifications, batch records, and product release for APIs and drug products, in compliance with company standards and cGMP procedures. The person will support Regulatory filings and inspections. They will work closely and support the Quality Management Systems (QMS) personnel.  This position reports to the Director of Quality.

Responsibilities: 

 The job responsibilities are:

• Drug Manufacturing
  • Develop and maintain essential quality systems for both development and commercial environments, including document control (including SOPs), exception management, change control, CAPA, training, validation, and auditing.
  • Participation in CMO selection, commissioning, qualification and certification.
  • Negotiation of quality agreements with contract manufacturers.
  • Approval of development, transfer, master and study specific validation protocols and reports.
  • Verification of process data and approval of technical protocols, reports, and chemistry, manufacturing and control sections of regulatory submissions.
  • Approval of production related activities via approval of: specifications, master batch records, change controls, sampling and testing plans, stability study protocols and reports.
  • Leading deviation and out of specification investigations.
  • Review of executed batch records and releasing API batches, certifying compliance with regulatory commitments/filings.
  • Support filing of Quality documents in Dot Compliance
• Quality Auditing:
  • Support QMS function in domestic and international audits of contract manufacturers, participating cross functionally with internal stakeholders to assure compliance with GMP regulations and Nurix Standards Operating Procedures (SOPs).
  • Support internal quality audits to assess Nurix’s GMP compliance.
  • Communicating audit findings to audit stakeholders ensuring understanding as well as collaborating with auditees to develop root cause Corrective and Preventive Action (CAPA) plans.
  • Maintaining databases for audit observations and CAPAs.
  • Tracking, reviewing, approving, and assessing the effectiveness of CAPAs.
• Competent Authority Inspections:
  • Facilitate and assist with the preparation, coordination, and management of Competent Authority inspections of Nurix and contract manufacturers.
  • Prepare contract manufacturers for Competent Authority GMP inspections, including pre-approval inspection.

The position will require interaction with senior management and executives on matters concerning the quality of products and contractor compliance. The incumbent is expected to work on complex problems in which analysis of situations or data requires an in-depth evaluation of various factors. They will be expected to exercise judgment within broadly defined regulations in selecting systems and evaluation criteria for obtaining results. They will support budgets, schedules, and performance requirements are met.

Qualification Requirements:

• Minimum of BS/BA in chemistry or related scientific field
• Minimum of 5 years of progressive quality assurance experience in clinical or commercial pharmaceutical operations and development; experience in both development and commercial operations required
• Advanced knowledge of Quality Assurance principles, concepts, industry practices and standards
• Strong proven hands-on experience with GMP compliance matters and contractor management in the bio/pharma industry. Knowledge of GLP and GCP plus
• Experience working with contract manufacturers
• Experience with the regulatory submission and approval process
• Strong knowledge of QA systems and company-wide SOP systems for all phases of clinical development
• Understanding scientific methods and the ability to interpret and communicate scientific data internally and externally
• Independent and self-directed
• Excellent communication and organizational skills
• Proficiency with eCTD software, document management systems, review management/version control software (eQMS systems), Microsoft Office and Adobe Acrobat
• Ability to travel as much as 50% or as required.

PHYSICAL DEMANDS:

While performing the duties of this job, the employee is required to stand, walk; sit; talk and hear. Specific vision abilities required by this job include close vision, distance vision, peripheral vision, depth perception and the ability to travel domestically and internationally.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. 

Position Overview:

The Senior Medical Science Liaison (Sr. MSL) will be a field-based representative of the Medical Affairs organization. The Sr. MSL will serve to develop and maintain working relationships with external collaborators and key opinion leaders within disease areas relevant to the company. The Sr. MSL will be the scientific regional expert.

Responsibilities:

• Develop and maintain relationships with principal investigators, key opinion leaders, and other external experts
• Demonstrate deep scientific expertise about pipeline and overall therapeutic areas to exchange relevant information and insights with external stakeholders
• Work with both the clinical and administrative departments, and the hospitals to create a collaborative and strong research relationship with clinical sites
• Support the education and training of site research staff on the clinical protocol and scientific rationale for products in partnership with clinical operations team
• Capture clinical experiences at sites to improve understanding of product performance
• Identify key national and regional thought leaders and any other external expert of interest (i.e., patient advocacy groups, digital opinion leaders, new investigators, etc.)
• Support clinical trial related activities, related to patient identification, recruitment and investigator education
• Help coordinate medical education to external stakeholders (patient advocacy groups, investigators, and other experts within the specific disease areas)
• Participate in the collection and exchange of scientific/technical information important to development efforts
• Distill feedback received from HCPs into meaningful insights that provide internal stakeholders with data to leverage cross-functional strategies
• Ensure all materials and activities reflect the highest standard of quality (i.e., material accurately referenced, correctly interpreted, and communicated appropriately)
• Identify, coordinate, evaluate and monitor research collaborations and/or investigator-sponsored trials intended to support the clinical and scientific strategy
• Represent the organization at major meetings and conferences relevant to research and development efforts
• Maintain clinical and technical expertise in the therapeutic area through review of the scientific literature and attendance at key scientific meetings
• Assist in the development of, and participate in, regional advisory boards and medical education programs
• Maintain cross-functional collaboration with internal teams including Clinical Operations, Clinical Development, and Medical Communications
• Other project work as assigned

Requirements:

Education and Experience:

• Advanced scientific or clinical degree (PhD, PharmD, NP or MD preferred) with a minimum of 8 years of experience in industry (i.e., biotech/pharmaceutical/medical device company, Contract Research Organization)
• 8 + years of experience as an MSL required
• Hematology oncology experience required; knowledge of B cell malignancies preferred

Competencies and Attributes:

• Proven ability to develop new clinical relationships and foster existing clinical relationships
• Ability to manage timelines, multiple priorities under time constraints
• Experience with clinical research, publication activities, congress/conference/academy presentations
• Aptitude to develop technical expertise in new therapeutic areas
• Strong analytical and problem-solving skills
• Ability to work effectively in a cross-functional environment
• Ability to cultivate and maintain relationships with clinical investigators and thought leaders and to establish trust through the consistent demonstration of scientific expertise and satisfactory follow-through to requests from external partners
• Strong leadership skills and the ability to compile and disseminate information to others in a cohesive fashion to assure a clear understanding of project status and direction.
• Excellent communicator, skilled at diplomacy and capable of effectively combining science and relationship building
• Field-based position – minimum of 50% travel required

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Description

Nurix is seeking a Senior/Principal Scientist, Pharmaceutical Development with expertise in lipid and ASD-based drug delivery systems to provide scientific, technical, and hands-on leadership of small molecule oral solid formulation development and manufacturing for pre-clinical through Phase 1 clinical trial stages. Responsibilities will include but are not limited to:

• Lead small molecule preclinical and clinical formulation development and characterization in support of internal Nurix development programs
• Manage outsourced development projects and manufacturing, including timeline and resource planning, to ensure milestones and deliverables are met efficiently
• Partner with Nurix Chemical Development and Analytical Development to identify optimal drug substance properties and control strategies
• Oversee preparation and characterization of pre-clinical drug products for in-house studies and partner with Global Supply Chain Operations for outsourced studies and clinical manufacturing
• Serve as drug product SME for cross-functional project teams
• Author and review relevant sections of regulatory filings, technical protocols, reports, etc.
• Manage and mentor research associates
• Contribute to internal and external presentations and publications.

Required Qualifications

• In depth knowledge and demonstrated expertise in the design, development, scale-up, and outsourced manufacture of oral lipid-based drug delivery systems
• Significant knowledge and experience with design, scale-up, and outsourced manufacture of amorphous solid dispersion-based formulations design (spray drying, hot melt extrusion, tableting and encapsulation); experience with other enabled oral formulation modes a plus
• Prior experience in formulation of targeted protein degrader molecules (aka CTMs, degraders, PROTACS) a plus
• Thorough understanding of analytical techniques used for pre-formulation and characterization of oral solid dose forms including HPLC, LC-MS, XRPD, DSC, Dissolution, and KF
• Excellent technical problem solving and troubleshooting abilities
• Excellent written and oral communications skills
• PhD (preferred) or MS in chemistry, pharmaceutics, engineering, or related field with at least 7 years relevant industrial experience
• Ability to travel up to 25% of time

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

We are seeking a highly motivated individual with a 2-4 years of lab experience with a background in purification of small molecule drug compounds by HPLC, milligram up to gram scale, to join the Analytical Chemistry group at Nurix located in The Woodlands, Texas.

This position will perform purifications of small molecule libraries by mass directed HPLC and support our early drug discovery efforts at Nurix. The candidate requires the ability to work in a fast-paced laboratory setting using state of the art analytical equipment and cloud-based data systems. This role requires hands on experience in maintenance and troubleshooting of chromatography instrumentation. This role also requires basic lab / chemical handling safety and the ability to lift 40 lbs.

The candidate should have a strong desire to learn new techniques, stay up to date with purification trends and an aptitude for robotic automation workflows. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in the dynamic team environment here at Nurix.

Required Qualifications

Minimum qualifications include a B.S. or equivalent degree in chemistry, analytical chemistry, or related field, with (2-4) years of industrial experience in analysis of small molecules, liquid chromatography, and mass spectroscopy.

Bonus Qualifications

Familiarity with Agilent ChemStation or similar chromatography software

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

Nurix is seeking a talented and motivated Software Engineer to join our dynamic Early Discovery team, specifically in the Machine Learning and Cheminformatics group. In this role, you will leverage your strong technical expertise to build reliable, performant, and scalable tools to advance our drug development platforms. You will work with a highly skilled and cross-functional team of scientist and engineers, designing innovative from end and back end software solutions supporting Nurix’s cutting edge research.  This position offers a unique opportunity to work at the intersection of biotechnology, machine learning, and high-performance computing, directly impacting the future of medicine. 

 Responsibilities 

• Maintain and enhance existing Python based code bases for the Machine Learning and Cheminformatics teams ensuring reliability, scalability, and performance
• Build and maintain scalable and responsive web applications that integrate with our machine learning and informatics platforms
• Develop roadmaps and implementation plans for new features and functionalities
• Develop and maintain complex database queries and integrations exposed as production-grade APIs
• Conduct thorough code reviews and ensure adherence to best practices 

 Desired Qualifications 

• Proficiency in Python and JavaScript with experience in object-oriented programming and common data structures.
• Strong knowledge of web building using Django, flask, CSS, html, htmx
• Familiarity with cloud computing platforms such as AWS (e.g., EC2, S3, Athena)
• Proven record of deploying and maintaining web applications
• Excellent communication and interpersonal skills with the ability to effectively collaborate with scientists and engineers. 

 Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

The Sr Director Business Insights & Analytics is responsible for market research, competitive intelligence, and forecasting for the Hematology assets of Nurix Therapeutics, and other assets and therapeutic areas as assigned.

The successful candidate will focus on critical business questions, drives towards strategic and synthesized insights, and suggests ideas and recommendations that enable better decision-making for the business.

This role will utilize advanced analytics to inform critical decisions for R&D, Business Development, New Product Planning, and the Commercial organization broadly. The ideal candidate for this role is a strategic, forward-thinking, analytics professional with a passion for fostering change and driving long-term sustained growth for the company.

Duties and Responsibilities:

• Drive robust delivery related to: Primary Market Research, Forecasting, Competitive Intelligence
• Lead and drive a thought partnership with brand teams and cross-functional partners to understand and address key business questions.
• In partnership with Brand Marketing, Sales Leadership, Finance, Patient Support, Market Access and other stakeholders, this role provides leadership in developing and executing the commercial strategy and plan by providing meaningful market and brand insights that enable effective data driven decision-making.
• Translates the business needs into actionable analytic-focused initiatives to provide solutions and/or recommendations to enable business excellence.
• Provide analytical insights through data analytics and market research to the Commercial teams to understand the business and identify potential opportunities for future growth.
• Lead sales forecasting and planning processes used within the Commercial organization and provide assessments of all business development opportunities to determine viability.
• Liaison between the Commercial organization and supply chain team to plan on optimal production and stocking of commercial product.
• Maintains a thorough understanding of the competitive landscape, market environment and product development to provide data-driven recommendations and consultation to Executive/Senior level leaders.
• Responsible for financial management of the function, including budgets, resources and ensuring productivity against impact is delivered.

Education and Qualifications

•  B.S. degree, advanced degree preferred.
• Experience launching products in biopharma industry (preferred).
• Hematology / Oncology experience (preferred).
• Strong command of analytical and market research techniques and experience with selection and management of vendors.
• Experience building and maintaining complex market assessments and forecast models.
• Ability to create and communicate a clear vision among direct reports, effectively aligning resources and motivating teams to achieve goals.
• A proven record of leading and delivering strategic initiatives for commercial executive leadership teams with tangible results using advanced analytics expertise.
• High business acumen with demonstrated ability to distill complex problems, create structured framing, assessments, and actionable recommendations in collaboration with cross-function/division colleagues.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

The Executive Director of Hematology Marketing will work cross-functionally and serve as an instrumental leader to enable the successful development and commercialization of Nurix Therapeutics Hematology assets.

How you will contribute

•    Establish strategic direction of pre-launch, launch and commercialization of Nurix assets in hematology. 
•    Drive Strategy and Launch Tactical Planning activities for key assets across multiple indications.
•    Partner to shape the Heme Disease Area Strategy, Brand Strategy and Brand Plan, including financial plan and forecasts, life cycle management

SCOPE :

•    Support the development of the strategic direction of Heme portfolio; validate growth opportunities and prioritize key activities
•    Drive the Global and US strategy and launch plans in Heme.
•    Drive insight generation and translate insights to messaging and brand storytelling in collaboration with Analytics and Insights; apply data and insights to validate business opportunities, optimize marketing mix and monitor ROI of brand activities
•    Lead the development and execution of tactical mix to drive brand performance.
•    Support LCM strategy for key assets by evaluating and prioritizing value driving indications. 

Required Qualifications

•    Bachelors Degree
•    At least 10 years pharmaceutical experience with increasing responsibilities in sales or marketing, including launching brands in the US market
•    At least 3-5 years of leadership experience – hired, developed and managed talent within the industry
•    Deep understanding of the pharmaceutical industry, with experience in either Hematology / Oncology 
•    Deep understanding of the brand/franchise, the pharmaceutical industry and how to effectively engage HCPs
•    Demonstrated ability to collaborate with functional partners and peers
•    Demonstrated experience managing complexity and change
•    Learning agility and adaptability
•    Ability to set priorities, manage roles and responsibilities of team, mentor and develop team members
•    Ability to make sound business decisions based on a strong understanding of business, finance and risks/benefits of decisions
•    Extensive experience in marketing strategy and tactic design with an ability to communicate ideas to internal partners and external agencies
•    Ability to clearly and succinctly communicate (verbally/written) in a persuasive and appropriate manner at the executive level 

Fit with Nurix Culture and Values
•    Strong team orientation; highly collaborative
•    Solutions and results-oriented focus
•    Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

The Vice President of Global Insights, Analytics, and Commercial Operations will drive Nurix Therapeutics vision for leveraging analytics to support strategic decision-making and operational excellence across the commercial organization. This leader will be pivotal in shaping and executing the company’s Global and US commercial analytics and operations strategy while fostering cross-functional collaboration and innovation. The key responsibilities include:

Primary Market Research: In close collaboration with Marketing and Market Access set the strategy and lead the execution of qualitative and quantitative insight generation for the company in support of Nurix Therapeutics assets ranging from pre-clinical to commercialization.

Competitive Intelligence: In close collaboration with Marketing, Medical Affairs, and Clinical Development set the strategy and lead the execution of competitive intelligence to collect important marketplace information to inform strategic and tactical plans in support of Nurix Therapeutics assets ranging from pre-clinical to commercialization.

Secondary Data Strategy and Application: Develop the data strategy, business rules, and plans to inform business decision making that drive investment allocation and deployment plans across the promotional mix. Additional responsibilities will include sales force sizing, business metric reporting, and incentive compensation.

Forecasting: Develop the forecasting models in support of each asset for Nurix Therapeutics, evaluate a range of scenarios to inform business planning both long term and short-term demand.

Commercial Operations: Lead commercial readiness for the organization, and lead important foundational commercial operational capabilities including Peer to Peer programing, Promotional Review Committee Operations, Contracting Services, Congresses and Meetings.

Qualifications

•  BS/BA degree in business or a related discipline; advanced degree (e.g., MBA, MPH) preferred.
•  At least 15 years of experience in the pharmaceutical or biotechnology industry.
• Strong experience in hematology / oncology is highly preferred, with a demonstrated ability to drive successful product launches.
•  Proven track record of successfully leading high-performing teams in hybrid, fast-paced environments, with the ability to make and stand by difficult decisions in a collaborative and compliant manner.
•  Deep experience influencing and collaborating with cross-functional teams and senior leadership, including interfacing with internal and external stakeholders, scientific teams, and commercial teams.
•  Strong business acumen, with the ability to deliver actionable recommendations and strategic insights to guide business decisions and drive growth.
•  Exceptional communication skills, capable of presenting effectively to both field teams and senior leadership, including the Board of Directors.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

We are seeking a dynamic and experienced Vice President of Marketing with extensive experience launching new hematology / oncology products and incorporating commercial strategy into early development programs. The core objective is to build, lead and execute all aspects of Nurix Therapeutics marketing efforts. This individual will be responsible for developing all marketing strategies and tactical readiness for the commercialization of Nurix Therapeutics assets. In addition, this role will be accountable for driving commercial strategy in support of lifecycle management and our pipeline. 

Accountable for developing and executing all Global and US Marketing strategies that align with the overall company strategic imperatives.
Ensure strategic alignment with cross-functional commercial partners in commercial insights and analytics, market access, and sales in order to produce high quality marketing efforts that achieve company performance objectives
•    Build and implement the marketing plan including, but not limited to, marketing strategy, brand development, promotions, digital marketing, patient marketing, and marketing operations
•    Develop and execute a comprehensive commercial strategy and set of tactical plans to ensure successful commercial launch of Nurix’s lead asset and subsequent assets in the US and other ex-US markets
•    Partner with commercial insights and analytics to develop and maintain deep market insights through market research, competitive intelligence, business analytics, necessary metrics/KPIs are in place to measure performance and identify opportunities as needed
•    Lead the development and implementation of commercial plans for potential future products including situation analysis, sizing/segmentation, positioning, messaging, and go-to-market commercial strategies
•    Partner with Clinical Development to inform trial design and prioritization of lifecycle plans and future pipeline assets
•    Maintain a high degree of presence, visibility, and ensure regular and effective communication with the field sales team to regularly solicit input, feedback, ideas, identify challenges and opportunities to deliver solutions as needed
•    Partner with commercial insights and analytics and finance to develop and maintain commercial forecasts, quarterly latest estimates, and operating budgets
•    Proactively develop and maintain close relationships with US and international Thought Leaders to inform commercial strategy
•    Ensure successfully agency and vendor partnerships
•    Participate in portfolio strategy and commercial evaluation of business development opportunities as needed
•    Provide input as needed to other business planning processes such as IC planning, CMC, budgeting, etc
•    Ability to travel (domestic and some international) to attend industry and team/field sales meetings, customer engagements, market research

Requirements:

•    Bachelors degree in business or related discipline required; MBA strongly preferred
•    Minimum of 15 years of experience within the biotech/pharmaceutical industry
•    U.S. Hematology/Oncology launch experience is required; Global launch experience strongly preferred
•    Experience building teams and commercial capabilities is required
•    Demonstrated ability to deliver results in competitive markets
•    Proven success collaborating closely with other commercial disciplines (market access, sales, operations, training, insights/analytics, etc)
•    Must be highly analytical, and comfortable with formulating and delivering data-driven, fact-based analysis of the business and utilizing insights to propose effective marketing strategies
•    Must be resourceful, demonstrate an agile and lean mindset approach, creative problem solver who seeks out and is receptive to new ideas and approaches to solving challenges
•    Ability to adapt to changes in the work environment, industry, manages competing demands
•    Outstanding written and verbal communication skills with the ability to effectively present to and engage with a wide range of audiences
•    Strategic thinking with the ability to drive results in a fast-paced and dynamic environment

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).